1. Remote ischemic preconditioning
ERICCA
Trial design: Patients undergoing CABG were randomized in a 1:1 fashion to either remote ischemic preconditioning or sham control. They were followed for 1 year.
Results
(p = 0.95)
Primary endpoint: CV death/MI/stroke/coronary revasc.: 26.6% vs. 28.0%, p = 0.95
CV death: 5.7% vs. 3.9%, p = 0.1; MI: 21.8% vs. 23.7%, p = 0.43
Perioperative AUC troponin T: 30,500 vs. 35,730 %
Conclusions
Remote ischemic preconditioning with the protocol followed in this trial does not impact on perioperative myocardial injury or 1-year CV outcomes in patients undergoing CABG
Other trials with ischemic preconditioning in CAD, especially STEMI (remote and direct) have been mostly negative
Primary endpoint
Remote ischemic preconditioning
(n = 801)
Sham control
(n = 811)
Presented by Dr. Derek Hausenloy at ACC 2015