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Clinical Gastroenterology and Hepatology

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Presentation on theme: "Clinical Gastroenterology and Hepatology"— Presentation transcript:

1 Clinical Gastroenterology and Hepatology
Efficacy and Safety of Besifovir Dipivoxil Maleate Compared With Tenofovir Disoproxil Fumarate in Treatment of Chronic Hepatitis B Virus Infection  Sang Hoon Ahn, Won Kim, Young Kul Jung, Jin Mo Yang, Jae Young Jang, Yong Oh Kweon, Yong Kyun Cho, Yoon Jun Kim, Gun Young Hong, Dong Joon Kim, Soon Ho Um, Joo Hyun Sohn, Jin Woo Lee, Sung Jae Park, Byung Seok Lee, Ju Hyun Kim, Hong Soo Kim, Seung Kew Yoon, Moon Young Kim, Hyung Joon Yim, Kwan Sik Lee, Young Suk Lim, Wan Sik Lee, Neung Hwa Park, So Young Jin, Kyun-Hwan Kim, Won Choi, Kwang-Hyub Han  Clinical Gastroenterology and Hepatology  DOI: /j.cgh Copyright © 2018 AGA Institute Terms and Conditions

2 Figure 1 Comparison of viral suppression between the BSV-BSV and TDF-BSV groups. (A) Proportion of patients with HBV DNA <69 IU/mL by study week. (B) Proportion of patients with HBV DNA <20 IU/mL by study week. Bars represent 95% confidence intervals. BSV, besifovir dipivoxil maleate; HBV, hepatitis B virus; TDF, tenofovir disoproxil fumarate. Clinical Gastroenterology and Hepatology DOI: ( /j.cgh ) Copyright © 2018 AGA Institute Terms and Conditions

3 Figure 2 Comparison of changes in BMD between the BSV-BSV and TDF-BSV groups. (A) Mean percentage changes in hip BMD at weeks 48 and 96 of treatment. Bars represent 95% confidence interval. (B) Mean percentage changes in spine BMD at weeks 48 and 96 of treatment. Bars represent 95% confidence intervals. BMD, bone mineral density; BSV, besifovir dipivoxil maleate; TDF, tenofovir disoproxil fumarate. Clinical Gastroenterology and Hepatology DOI: ( /j.cgh ) Copyright © 2018 AGA Institute Terms and Conditions

4 Figure 3 Changes in estimated glomerular filtration rate from baseline by study week. Data are presented as median (Q1, Q3) values (mL/min) calculated by using the Modification of Diet in Renal Disease. BSV, besifovir dipivoxil maleate; TDF, tenofovir disoproxil fumarate. Clinical Gastroenterology and Hepatology DOI: ( /j.cgh ) Copyright © 2018 AGA Institute Terms and Conditions

5 Supplementary Figure 1 Patient disposition. BSV, besifovir dipivoxil maleate; CPK, creatine phosphokinase; HCC, hepatocellular carcinoma; TDF, tenofovir disoproxil fumarate. Clinical Gastroenterology and Hepatology DOI: ( /j.cgh ) Copyright © 2018 AGA Institute Terms and Conditions

6 Supplementary Figure 2 Safety results of bone mineral density in terms of T-score changes from baseline. BSV, besifovir dipivoxil maleate; TDF, tenofovir disoproxil fumarate. Clinical Gastroenterology and Hepatology DOI: ( /j.cgh ) Copyright © 2018 AGA Institute Terms and Conditions

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