1. Resolving Lipids: Lipoxins Regulate Reverse Cholesterol Transport
Matthew Spite 
Cell Metabolism 
Volume 20, Issue 6, Pages (December 2014)
DOI: /j.cmet
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2. Figure 1 Regulation of Cholesterol Metabolism by Lipid Mediators
Arachidonic acid is converted to prostaglandins (PGs) by cyclooxygenase (COX) enzymes. Aspirin inhibits the production of PGs and results in substrate diversion of AA to lipoxygenase (LOX) pathways in the liver and also promotes the generation of 15-epimeric lipoxins. Arachidonate 5-lipoxygenase (Alox5) is involved in the biosynthesis of leukotriene B4 (LTB4) and the lipoxins, LXA4 (5S, 6R, 15S- trihydroxy- 7E, 9E, 11Z, 13E- eicosatetraenoic acid) and LXB4 (5S, 14R, 15S- trihydroxy- 6E, 8Z, 10E, 12E- eicosatetraenoic acid). Aspirin treatment enhances reverse cholesterol transport in part by increasing the production of Alox5-derived mediators and subsequent bile acid secretion through ATP-binding cassette subfamily b member 11 (Abcb11). These protective actions are recapitulated by administration of stable analogs of LXB4 (i.e., 5-R/S-methyl LXB4).
Cell Metabolism  , DOI: ( /j.cmet )
Copyright © 2014 Elsevier Inc. Terms and Conditions