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Volume 55, Issue 2, Pages (February 1999)

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1 Volume 55, Issue 2, Pages 424-429 (February 1999)
Intrauterine growth restriction is associated with persistent juxtamedullary expression of renin in the fetal kidney  John C.P. Kingdom, Mark Hayes, James Mcqueen, Allan G. Howatson, George B.M. Lindop  Kidney International  Volume 55, Issue 2, Pages (February 1999) DOI: /j x Copyright © 1999 International Society of Nephrology Terms and Conditions

2 Figure 1 Diagrammatic map of a histologic section of an intrauterine growth restricted (IUGR) fetal renal cortex at 28weeks of gestation divided into three bands of equal width. Note the predominance of immature glomeruli (I) in the outer (nephrogenic) zone. Mature glomeruli are shown as O, and individual renin-containing cells (RCCs) are marked as small black dots. Kidney International  , DOI: ( /j x) Copyright © 1999 International Society of Nephrology Terms and Conditions

3 Figure 2 Histologic sections of fetal kidney demonstrating renin-containing cells (RCCs, arrows) containing immunoreactive renin by the immunoperoxidase technique. RCCs (arrows) located in an arteriole near to a radial artery (A). An adjacent section (B) following in situ hybridization using a riboprobe complementary to human renin mRNA indicates synthesis (arrows) at the same site. A denotes a radial artery. Kidney International  , DOI: ( /j x) Copyright © 1999 International Society of Nephrology Terms and Conditions

4 Figure 3 Change in density of RCCs in the inner, middle, and outer zones of the renal cortex with gestational age for control (○) and growth-restricted (IUGR; •) fetuses. Linear regression lines are shown. Kidney International  , DOI: ( /j x) Copyright © 1999 International Society of Nephrology Terms and Conditions

5 Figure 4 Maturation of the renal cortex in control (○) and growth-restricted (IUGR; •) fetuses was assessed by the proportion of immature glomeruli remaining in the outer cortical zone as gestation advanced. Linear regression lines are shown for analysis of cases ≥25weeks gestation. Kidney International  , DOI: ( /j x) Copyright © 1999 International Society of Nephrology Terms and Conditions


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