1. Volume 44, Issue 4, Pages 829-831 (April 2006)
Liver transplantation in an adult with sclerosing cholangitis due to Langerhans cell histiocytosis 
William Griffiths, Susan Davies, Paul Gibbs, Andrew Thillainayagam, Graeme Alexander 
Journal of Hepatology 
Volume 44, Issue 4, Pages (April 2006)
DOI: /j.jhep
Copyright © 2006 European Association for the Study of the Liver Terms and Conditions

2. Fig. 1
Endoscopic retrograde cholangiopancreatography (ERCP) showing appearances consistent with extensive sclerosing cholangitis.
Journal of Hepatology  , DOI: ( /j.jhep )
Copyright © 2006 European Association for the Study of the Liver Terms and Conditions

3. Fig. 2
Macroscopic appearance of explanted liver. The organ has mottled bile-stained discolouration due to severe cholestasis but a smooth non-cirrhotic capsular surface.
Journal of Hepatology  , DOI: ( /j.jhep )
Copyright © 2006 European Association for the Study of the Liver Terms and Conditions

4. Fig. 3
Infiltration by Langerhans cells. Panel A shows a massively expanded portal tract with a cellular infiltrate and marginal ductular proliferation. Pre-existing portal structures are shown (arrow) (H–E ×40). The infiltrate (B) consists of eosinophils and large mononuclear cells with cleaved nuclei (H–E ×400). These cells are positive for CD1a (C) consistent with Langerhans cells (×200).
Journal of Hepatology  , DOI: ( /j.jhep )
Copyright © 2006 European Association for the Study of the Liver Terms and Conditions

5. Fig. 4
Focal liver abnormalities. Panel A shows sub capsular infiltrates of S100-positive (Langerhans) cells (×20). Florid ductular proliferation is seen in a portal tract (B) with bile plugging in the parenchyma (arrows) (H–E ×100). Ductopenia is evident in other portal tracts (C) (A, artery, V, vein, H–E ×400). In panel D, a major interlobar bile duct is seen infiltrated by CD1a-positive Langerhans cells (×200).
Journal of Hepatology  , DOI: ( /j.jhep )
Copyright © 2006 European Association for the Study of the Liver Terms and Conditions