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Calibration of Quality-Adjusted Life Years for Oncology Clinical Trials  Jeff A. Sloan, PhD, Daniel J. Sargent, PhD, Paul J. Novotny, MS, Paul A. Decker,

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Presentation on theme: "Calibration of Quality-Adjusted Life Years for Oncology Clinical Trials  Jeff A. Sloan, PhD, Daniel J. Sargent, PhD, Paul J. Novotny, MS, Paul A. Decker,"— Presentation transcript:

1 Calibration of Quality-Adjusted Life Years for Oncology Clinical Trials 
Jeff A. Sloan, PhD, Daniel J. Sargent, PhD, Paul J. Novotny, MS, Paul A. Decker, MS, Randolph S. Marks, MD, Heidi Nelson, MD  Journal of Pain and Symptom Management  Volume 47, Issue 6, Pages e3 (June 2014) DOI: /j.jpainsymman Copyright © 2014 U.S. Cancer Pain Relief Committee Terms and Conditions

2 Fig. 1 Power for n=300 per group, HR=1.0, 10% toxicity in the reference arm, and varying the toxicity rate in the other arm. Journal of Pain and Symptom Management  , e3DOI: ( /j.jpainsymman ) Copyright © 2014 U.S. Cancer Pain Relief Committee Terms and Conditions

3 Fig. 2 Power for double toxicity rate in one arm and utility of 0.3 for varying sample sizes and hazard rates. Journal of Pain and Symptom Management  , e3DOI: ( /j.jpainsymman ) Copyright © 2014 U.S. Cancer Pain Relief Committee Terms and Conditions

4 Fig. 3 Power for n=300 per group, HR=1.0, and Ut=0.3 for varying toxicity rates in the reference and other arm. Journal of Pain and Symptom Management  , e3DOI: ( /j.jpainsymman ) Copyright © 2014 U.S. Cancer Pain Relief Committee Terms and Conditions

5 Fig. 4 Power for n=300 per group, HR=1.0, and Ut=0.3 for varying toxicity rates in the reference and other arm. Journal of Pain and Symptom Management  , e3DOI: ( /j.jpainsymman ) Copyright © 2014 U.S. Cancer Pain Relief Committee Terms and Conditions

6 Journal of Pain and Symptom Management 2014 47, 1091-1099. e3DOI: (10
Journal of Pain and Symptom Management  , e3DOI: ( /j.jpainsymman ) Copyright © 2014 U.S. Cancer Pain Relief Committee Terms and Conditions

7 Journal of Pain and Symptom Management 2014 47, 1091-1099. e3DOI: (10
Journal of Pain and Symptom Management  , e3DOI: ( /j.jpainsymman ) Copyright © 2014 U.S. Cancer Pain Relief Committee Terms and Conditions

8 Journal of Pain and Symptom Management 2014 47, 1091-1099. e3DOI: (10
Journal of Pain and Symptom Management  , e3DOI: ( /j.jpainsymman ) Copyright © 2014 U.S. Cancer Pain Relief Committee Terms and Conditions

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