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Bronchial Oncocytoma With High 18F-Fluorodeoxyglucose Uptake Revealed by Nephrotic Syndrome  Giovanni Leuzzi, MD, Alfredo Cesario, MD, Marco Chiappetta,

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Presentation on theme: "Bronchial Oncocytoma With High 18F-Fluorodeoxyglucose Uptake Revealed by Nephrotic Syndrome  Giovanni Leuzzi, MD, Alfredo Cesario, MD, Marco Chiappetta,"— Presentation transcript:

1 Bronchial Oncocytoma With High 18F-Fluorodeoxyglucose Uptake Revealed by Nephrotic Syndrome 
Giovanni Leuzzi, MD, Alfredo Cesario, MD, Marco Chiappetta, MD, Filippo Lococo, MD, Gianluigi Petrone, MD, Maria Teresa Congedo, MD, Guido Rindi, PhD, Pierluigi Granone, PhD  Journal of Thoracic Oncology  Volume 7, Issue 9, Pages e9-e11 (September 2012) DOI: /JTO.0b013e31825ccace Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions

2 Figure 1 Computed tomography scan revealed the tumor localized in the right inferior lobe, measuring 1.3 cm in the major axis. Magnification shows the endobronchial feature of the lesion. Journal of Thoracic Oncology 2012 7, e9-e11DOI: ( /JTO.0b013e31825ccace) Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions

3 Figure 2 The PET-CT scan characterized the endobronchial nodule with an SUV of 12. No local or distant metastases were detected. Journal of Thoracic Oncology 2012 7, e9-e11DOI: ( /JTO.0b013e31825ccace) Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions

4 Figure 3 A, The neoplastic mass within the bronchial wall causing compression of the bronchial lumen. The tumor exhibited a nodular growth pattern (haematoxylin and eosin; original magnification × 20). B, The tumor was arranged in organoid and trabecular clusters separated by thin fibrovascular stroma. Notably, some clusters exhibit metaplastic bone formation. Neoplastic cells showed a large, eosinophilic, finely granular cytoplasm with large, round to oval, vesicular nuclei with coarse chromatin and small nucleoli. The mitotic count was less than 2 mitosis × 10 high-power fields and no necrosis was observed (haematoxylin and eosin; original magnification × 200). C. Many of the neoplastic cells seemed markedly stained for glucose transporter protein in a membrane pattern (haematoxylin counterstaining; original magnification × 200). D, The proliferative index was less than 2% (MIB1/Ki67) (haematoxylin counterstaining; original magnification × 100). E, No immunostaining was observed for chromogranin A, synaptofisin and CD56-NCAM; some epithelial bronchial cells were stained for chromogranin A (onset) (Haematoxylin counterstaining; original magnification × 100.) Journal of Thoracic Oncology 2012 7, e9-e11DOI: ( /JTO.0b013e31825ccace) Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions

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