Presentation is loading. Please wait.

Presentation is loading. Please wait.

Patricia Díaz-Gimeno, Ph. D. , José A. Horcajadas, Ph. D. , José A

Similar presentations


Presentation on theme: "Patricia Díaz-Gimeno, Ph. D. , José A. Horcajadas, Ph. D. , José A"— Presentation transcript:

1 A genomic diagnostic tool for human endometrial receptivity based on the transcriptomic signature 
Patricia Díaz-Gimeno, Ph.D., José A. Horcajadas, Ph.D., José A. Martínez-Conejero, Ph.D., Francisco J. Esteban, Ph.D., Pilar Alamá, M.D., Antonio Pellicer, M.D., Carlos Simón, M.D.  Fertility and Sterility  Volume 95, Issue 1, Pages e15 (January 2011) DOI: /j.fertnstert Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

2 Figure 1 Hierarchical clustering of the 68 samples from the menstrual cycle (groups P, PR, and R). Samples are represented in vertical and values of gene expression in horizontal. Color indicates gene expression value intensities (blue = low; red = high). See text for explanation of sample groups. Fertility and Sterility  , e15DOI: ( /j.fertnstert ) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

3 Figure 2 Gene clustering of ERA genes. Proliferative phase is named as 7 (day 7), prereceptives as 14 (day 14), and receptive as 21 (day 21). Gene number belonging to each cluster is indicated at the bottom of the graphic. Fertility and Sterility  , e15DOI: ( /j.fertnstert ) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

4 Figure 3 Endometrial receptivity transcriptomic signature. (A) Gene selection: intersection between genes statistically significant in groups R versus PR and R versus P. Number of genes up-regulated and down-regulated in each comparison and in the intersection is indicated. (B) The t-statistic average for the 134 genes of the endometrial receptivity signature (74 up-regulated and 60 down-regulated). See text for explanation of sample groups. Fertility and Sterility  , e15DOI: ( /j.fertnstert ) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

5 The RT-PCR validation for the ERA genes: GPx3, FDYX2, SPP1, and MT1G
The RT-PCR validation for the ERA genes: GPx3, FDYX2, SPP1, and MT1G. Blue bars indicate fold change in microarray data and red bars indicate fold change by RT-PCR. GPx3 = glutathione peroxidase 3; FDYX2 - FXYD = domain containing ion transport regulator 2; SPP1 = secreted phosphoprotein 1; MT1G = metallothionein 1G. Fertility and Sterility  , e15DOI: ( /j.fertnstert ) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions


Download ppt "Patricia Díaz-Gimeno, Ph. D. , José A. Horcajadas, Ph. D. , José A"

Similar presentations


Ads by Google