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A 33-Year-Old Man With Multiple Bilateral Pulmonary Pseudoaneurysms

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Presentation on theme: "A 33-Year-Old Man With Multiple Bilateral Pulmonary Pseudoaneurysms"— Presentation transcript:

1 A 33-Year-Old Man With Multiple Bilateral Pulmonary Pseudoaneurysms
Haala K. Rokadia, MD, Gustavo A. Heresi, MD, Carmela D. Tan, MD, Daniel P. Raymond, MD, George Thomas Budd, MD, Carol Farver, MD  CHEST  Volume 148, Issue 4, Pages e112-e117 (October 2015) DOI: /chest Copyright © 2015 The American College of Chest Physicians Terms and Conditions

2 Figure 1 A-D, CT scan of the chest with contrast demonstrates eccentric filling defects in multiple pulmonary artery branches bilaterally (A, D, green arrows) with aneurysmal formation of distal segmental/subsegmental arteries bilaterally (B, D, yellow arrows). A-C, Representative axial images demonstrating bilateral disease involving multiple pulmonary artery branches. D, Representative coronal image. CHEST  , e112-e117DOI: ( /chest ) Copyright © 2015 The American College of Chest Physicians Terms and Conditions

3 Figure 2 Hematoxylin and eosin stain at low power that demonstrates ectatic vessel that is larger than adjacent airway. Myxoma cells are invading the vascular wall (original magnification × 12.5). CHEST  , e112-e117DOI: ( /chest ) Copyright © 2015 The American College of Chest Physicians Terms and Conditions

4 Figure 3 Movat stain at higher power that demonstrates the myxoid background breaking down the elastica and invading the perivascular tissue. This Movat stain highlights the connective tissue repair processes in the vessel wall secondary to the tumor invasion. The blue highlights deposition of mucopolysaccharides in the early collagen, and the yellow highlights the more chronic collagen deposition and the irreversible fibrosis (original magnification × 40). CHEST  , e112-e117DOI: ( /chest ) Copyright © 2015 The American College of Chest Physicians Terms and Conditions

5 Figure 4 A, Immunohistochemical study of calretinin reveals myxoma cells invading through vessel wall into surrounding alveolar tissue (anticalretinin with hematoxylin counterstain; original magnification × 40). B, Myxoma cells with brown staining from anticalretinin antibody (anticalretinin with hematoxylin counterstain; original magnification × 400). CHEST  , e112-e117DOI: ( /chest ) Copyright © 2015 The American College of Chest Physicians Terms and Conditions

6 Figure 5 Cardiac MRI that demonstrates no intracardiac masses.
CHEST  , e112-e117DOI: ( /chest ) Copyright © 2015 The American College of Chest Physicians Terms and Conditions


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