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Published byLennart Gorm Henriksen Modified over 5 years ago
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Hypercholesterolemia and oxidative stress inhibit endothelial cell healing after arterial injury
Michael A. Rosenbaum, MD, Keiko Miyazaki, MD, Linda M. Graham, MD Journal of Vascular Surgery Volume 55, Issue 2, Pages (February 2012) DOI: /j.jvs Copyright © 2012 Society for Vascular Surgery Terms and Conditions
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Fig 1 Representative carotid arteries 120 hours after electrical injury for mice in the chow group (A) and the high-cholesterol (HC) group (B). The stained area represents the denuded section of artery. The arrow represents the length of the original injury used to calculate the re-endothelialized area. Re-endothelialization following carotid electrical injury is reported as the area re-endothelialized relative to the total area of injury and expressed as the mean ± standard error for mice in the chow group (n = 5) and in the HC group (n = 5) (C). Journal of Vascular Surgery , DOI: ( /j.jvs ) Copyright © 2012 Society for Vascular Surgery Terms and Conditions
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Fig 2 Representative carotid arteries 108 hours after air-drying injury for mice in the chow group (A) and high-cholesterol (HC) group (B). The stained area represents the denuded section of artery. The arrow represents the length of the original injury used to calculate the re-endothelialized area. Re-endothelialization following carotid air injury is reported as the area re-endothelialized relative to a 4-mm length of the original injury and expressed as the mean ± standard error for mice in the chow group (n = 7) and in the HC group (n = 10) (C). Journal of Vascular Surgery , DOI: ( /j.jvs ) Copyright © 2012 Society for Vascular Surgery Terms and Conditions
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Fig 3 Re-endothelialization of mouse carotid arteries 120 hours after electrical injury reported as the area re-endothelialized relative to the total area of injury and expressed as the mean ± standard error for mice in each group: chow (n = 5), chow plus N-acetylcysteine (NAC, n = 5), high cholesterol (HC) (n = 5), HC plus NAC (n = 5), chow plus paraquat (PQ, n = 5), chow plus PQ plus NAC (n = 5), HC plus PQ (n = 5), and HC plus PQ plus NAC (n = 5). Journal of Vascular Surgery , DOI: ( /j.jvs ) Copyright © 2012 Society for Vascular Surgery Terms and Conditions
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