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Glenn C. Hunter, MD, Stephen H. Smyth, MD, Marie L. Aguirre, MD, B

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Presentation on theme: "Glenn C. Hunter, MD, Stephen H. Smyth, MD, Marie L. Aguirre, MD, B"— Presentation transcript:

1 Incidence and histologic characteristics of blebs in patients with abdominal aortic aneurysms 
Glenn C. Hunter, MD, Stephen H. Smyth, MD, Marie L. Aguirre, MD, B.Timothy Baxter, MD, David A. Bull, MD, David D. King, MD, Yi P. Wang, MD, Kevin A. Hall, MD, Charles W. Putnam, MD  Journal of Vascular Surgery  Volume 24, Issue 1, Pages (July 1996) DOI: /S (96) Copyright © 1996 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

2 Fig. 1 Contrast-enhanced CT scan demonstrates large calcified bleb on right posterior lateral wall of aneurysm. Journal of Vascular Surgery  , DOI: ( /S (96) ) Copyright © 1996 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

3 Fig. 2 Contrast-enhanced CT scan shows inferior mesenteric artery.
Journal of Vascular Surgery  , DOI: ( /S (96) ) Copyright © 1996 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

4 Fig. 3 Operative photograph demonstrates typical bleb.
Journal of Vascular Surgery  , DOI: ( /S (96) ) Copyright © 1996 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

5 Fig. 4 Photomicrograph of bleb demonstrates absence of elastic lamellae near apex; only scattered elastic tissue fragments (arrows) are present (elastochrome; original magnification, 40×). Inset: High-power view of apex of bleb confirms absence of elastic tissue elements. Journal of Vascular Surgery  , DOI: ( /S (96) ) Copyright © 1996 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

6 Fig. 5 A, Photomicrograph of bleb demonstrates typical findings of fibrosis, inflammatory cell infiltrate of lymphocytes, macrophages, and proliferation of capillaries (hematoxylin and eosin; original magnification, 40×). B, Immunohiostochemical stain of bleb wall demonstrates macrophages (CD 68; original magnification, 50×). C, Immunohistochemical stain of bleb wall shows capillaries adjacent to inflammatory cell infiltrate (factor VII; original magnification, 60x). D, Section of bleb wall demonstrates T lymphocytes (CD43; original magnification 60x). Journal of Vascular Surgery  , DOI: ( /S (96) ) Copyright © 1996 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

7 Fig. 5 A, Photomicrograph of bleb demonstrates typical findings of fibrosis, inflammatory cell infiltrate of lymphocytes, macrophages, and proliferation of capillaries (hematoxylin and eosin; original magnification, 40×). B, Immunohiostochemical stain of bleb wall demonstrates macrophages (CD 68; original magnification, 50×). C, Immunohistochemical stain of bleb wall shows capillaries adjacent to inflammatory cell infiltrate (factor VII; original magnification, 60x). D, Section of bleb wall demonstrates T lymphocytes (CD43; original magnification 60x). Journal of Vascular Surgery  , DOI: ( /S (96) ) Copyright © 1996 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

8 Fig. 5 A, Photomicrograph of bleb demonstrates typical findings of fibrosis, inflammatory cell infiltrate of lymphocytes, macrophages, and proliferation of capillaries (hematoxylin and eosin; original magnification, 40×). B, Immunohiostochemical stain of bleb wall demonstrates macrophages (CD 68; original magnification, 50×). C, Immunohistochemical stain of bleb wall shows capillaries adjacent to inflammatory cell infiltrate (factor VII; original magnification, 60x). D, Section of bleb wall demonstrates T lymphocytes (CD43; original magnification 60x). Journal of Vascular Surgery  , DOI: ( /S (96) ) Copyright © 1996 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

9 Fig. 5 A, Photomicrograph of bleb demonstrates typical findings of fibrosis, inflammatory cell infiltrate of lymphocytes, macrophages, and proliferation of capillaries (hematoxylin and eosin; original magnification, 40×). B, Immunohiostochemical stain of bleb wall demonstrates macrophages (CD 68; original magnification, 50×). C, Immunohistochemical stain of bleb wall shows capillaries adjacent to inflammatory cell infiltrate (factor VII; original magnification, 60x). D, Section of bleb wall demonstrates T lymphocytes (CD43; original magnification 60x). Journal of Vascular Surgery  , DOI: ( /S (96) ) Copyright © 1996 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

10 Fig. 6 Composite micrograph of plaque from aorta affected by atherosclerotic occlusive disease after hybridization to α 1 (I) procollagen probe (HF-677) and counterstaining with hematoxylin and eosin. Positive signal is noted in myofibroblasts within the plaque. Box in A outlines area shown under higher magnification in B and C. Arrows in B and C indicate corresponding cells in light- and dark-field images (original magnification: A, 200x; B, 400x; C, 400x dark field). Journal of Vascular Surgery  , DOI: ( /S (96) ) Copyright © 1996 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

11 Fig. 6 Composite micrograph of plaque from aorta affected by atherosclerotic occlusive disease after hybridization to α 1 (I) procollagen probe (HF-677) and counterstaining with hematoxylin and eosin. Positive signal is noted in myofibroblasts within the plaque. Box in A outlines area shown under higher magnification in B and C. Arrows in B and C indicate corresponding cells in light- and dark-field images (original magnification: A, 200x; B, 400x; C, 400x dark field). Journal of Vascular Surgery  , DOI: ( /S (96) ) Copyright © 1996 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

12 Fig. 6 Composite micrograph of plaque from aorta affected by atherosclerotic occlusive disease after hybridization to α 1 (I) procollagen probe (HF-677) and counterstaining with hematoxylin and eosin. Positive signal is noted in myofibroblasts within the plaque. Box in A outlines area shown under higher magnification in B and C. Arrows in B and C indicate corresponding cells in light- and dark-field images (original magnification: A, 200x; B, 400x; C, 400x dark field). Journal of Vascular Surgery  , DOI: ( /S (96) ) Copyright © 1996 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

13 Fig. 7 Composite micrograph of aneurysmal aortic tissue after hybridization to α 1 (I) procollagen (HF-677) and counterstaining with hematoxylin and eosin. A, Typical inflammatory infiltrate is seen at junction of medial-adventitial border (arrow). Box outlines the area shown under higher magnification in B and C. B and C, Arrows indicate corresponding cells in light- and dark-field images. Under higher power, positive cells are identified in the media. The positive signal is strongest near the inflammatory infiltrate and decreases with increasing distance from it (original magnification: A, 200×; B, 400×; C, 400×; dark field) Journal of Vascular Surgery  , DOI: ( /S (96) ) Copyright © 1996 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

14 Fig. 7 Composite micrograph of aneurysmal aortic tissue after hybridization to α 1 (I) procollagen (HF-677) and counterstaining with hematoxylin and eosin. A, Typical inflammatory infiltrate is seen at junction of medial-adventitial border (arrow). Box outlines the area shown under higher magnification in B and C. B and C, Arrows indicate corresponding cells in light- and dark-field images. Under higher power, positive cells are identified in the media. The positive signal is strongest near the inflammatory infiltrate and decreases with increasing distance from it (original magnification: A, 200×; B, 400×; C, 400×; dark field) Journal of Vascular Surgery  , DOI: ( /S (96) ) Copyright © 1996 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

15 Fig. 7 Composite micrograph of aneurysmal aortic tissue after hybridization to α 1 (I) procollagen (HF-677) and counterstaining with hematoxylin and eosin. A, Typical inflammatory infiltrate is seen at junction of medial-adventitial border (arrow). Box outlines the area shown under higher magnification in B and C. B and C, Arrows indicate corresponding cells in light- and dark-field images. Under higher power, positive cells are identified in the media. The positive signal is strongest near the inflammatory infiltrate and decreases with increasing distance from it (original magnification: A, 200×; B, 400×; C, 400×; dark field) Journal of Vascular Surgery  , DOI: ( /S (96) ) Copyright © 1996 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

16 Fig. 8 A, Photomicrograph of aortic bleb after hybridization to α 1 (I) procollagen probe (HF-677) and counterstaining with hematoxylin and eosin. A lymphocytic infiltrate is seen in the aortic wall adjacent to a bleb (arrow). B, Despite prolonged exposure, no specific binding of the probe to α 1 (I) procollagen mRNA could be identified (original magnification, 400×). Journal of Vascular Surgery  , DOI: ( /S (96) ) Copyright © 1996 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

17 Fig. 8 A, Photomicrograph of aortic bleb after hybridization to α 1 (I) procollagen probe (HF-677) and counterstaining with hematoxylin and eosin. A lymphocytic infiltrate is seen in the aortic wall adjacent to a bleb (arrow). B, Despite prolonged exposure, no specific binding of the probe to α 1 (I) procollagen mRNA could be identified (original magnification, 400×). Journal of Vascular Surgery  , DOI: ( /S (96) ) Copyright © 1996 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

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