1. Magnetic resonance imaging in Alzheimer's Disease Neuroimaging Initiative 2 
Clifford R. Jack, Josephine Barnes, Matt A. Bernstein, Bret J. Borowski, James Brewer, Shona Clegg, Anders M. Dale, Owen Carmichael, Christopher Ching, Charles DeCarli, Rahul S. Desikan, Christine Fennema-Notestine, Anders M. Fjell, Evan Fletcher, Nick C. Fox, Jeff Gunter, Boris A. Gutman, Dominic Holland, Xue Hua, Philip Insel, Kejal Kantarci, Ron J. Killiany, Gunnar Krueger, Kelvin K. Leung, Scott Mackin, Pauline Maillard, Ian B. Malone, Niklas Mattsson, Linda McEvoy, Marc Modat, Susanne Mueller, Rachel Nosheny, Sebastien Ourselin, Norbert Schuff, Matthew L. Senjem, Alix Simonson, Paul M. Thompson, Dan Rettmann, Prashanthi Vemuri, Kristine Walhovd, Yansong Zhao, Samantha Zuk, Michael Weiner 
Alzheimer's & Dementia: The Journal of the Alzheimer's Association 
Volume 11, Issue 7, Pages (July 2015)
DOI: /j.jalz
Copyright © 2015 The Authors Terms and Conditions

2. Fig. 1
Tensor-based morphometry (TBM). This figure, adapted from Hua et al. [25] shows how TBM can visualize the profiles of brain tissue loss and expansion, throughout the brain, in this case over a 12-month interval. These average maps of brain tissue loss for different diagnostic groups can be summarized to produce single “numeric summaries” of atrophy rates, as a percentage per year. Brain regions offering greatest group discrimination included the temporal lobes (shown in blue), or specially defined regions within them.
Alzheimer's & Dementia: The Journal of the Alzheimer's Association  , DOI: ( /j.jalz )
Copyright © 2015 The Authors Terms and Conditions

3. Fig. 2
Boundary shift integral (BSI). Coronal, volumetric (three-dimensional or 3D) T1-weighted MRI scans from the same individual scanned at baseline and after an interval are shown. The second scan is aligned (spatially registered) to the first. Atrophy occurring between the two scans results in a shift at the brain/cerebrospinal fluid (CSF) interface (green overlay on third image). The BSI, the sum of the displacement of the brain/CSF boundary across the whole brain, provides a means of quantifying atrophy occurring between the two scans.
Alzheimer's & Dementia: The Journal of the Alzheimer's Association  , DOI: ( /j.jalz )
Copyright © 2015 The Authors Terms and Conditions