1. Understanding Protein-Protein Interactions on Biosensor Surfaces
Vincent Chang
Mentor: Lisa Plucinski

2. Overview Learn how to use the COMSOL application
Use COMSOL models to understand the fundamentals of reaction kinetics and surface binding

3. Program Used COMSOL Multiphysics 5.1 Transport and Adsorption
Modeling phenomena of surface binding in different dimensions (3D to 2D).

4. Progress
Creating a 2D model that displays the concentration of the reacting species at various areas of the surface through time
Understanding the physics behind why surface concentration of reacting species vary through position and time
Understanding reaction rates on surface binding through time

8. Future Goals
Obtain experimental data for biotin-streptavidin binding on a biosensor with a microfluidic channel
Explore how various experimental parameters impact protein-binding kinetics
Explore methods to fit experimental data to models

9. Sources
All information is received through COMSOL Multiphysics 5.1 Transport and Adsorption