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Phase-I/II Study of Bortezomib in Combination with Carboplatin and Bevacizumab as First-Line Therapy in Patients With Advanced Non–Small-Cell Lung Cancer 

Published byΆνθεια Καλάρης Modified over 5 years ago

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Presentation on theme: "Phase-I/II Study of Bortezomib in Combination with Carboplatin and Bevacizumab as First-Line Therapy in Patients With Advanced Non–Small-Cell Lung Cancer "— Presentation transcript:

1 Phase-I/II Study of Bortezomib in Combination with Carboplatin and Bevacizumab as First-Line Therapy in Patients With Advanced Non–Small-Cell Lung Cancer  Bilal Piperdi, MD, William V. Walsh, MD, Kendra Bradley, RN, Zheng Zhou, MD, PhD, Venu Bathini, MD, Meredith Hanrahan-Boshes, RN, Lloyd Hutchinson, PhD, Roman Perez-Soler, MD  Journal of Thoracic Oncology  Volume 7, Issue 6, Pages (June 2012) DOI: /JTO.0b013e31824de2fa Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions

2 FIGURE 1 Computed tomography scans showing partial responses. A, Lung nodule in patient #8 prechemotherapy; (B) post two cycles; (C) hilar mass and malignant pleural effusion in patient #11 prechemotherapy; and (D) post four cycles, marked reduction in hilar mass and complete resolution of malignant pleural effusion. Journal of Thoracic Oncology 2012 7, DOI: ( /JTO.0b013e31824de2fa) Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions

3 FIGURE 2 Kaplan-Meier plots for (A) PFS of all patients; (B) OS of all patients; and (C) PFS and OS of patients treated in cohort 3 (recommended phase-II dose). PFS, progression-free survival; OS, overall survival. Journal of Thoracic Oncology 2012 7, DOI: ( /JTO.0b013e31824de2fa) Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions

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