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Anne Dørum, Ketil Heimdal, Eivind Hovig, Mats Inganäs, Pål Møller 

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Presentation on theme: "Anne Dørum, Ketil Heimdal, Eivind Hovig, Mats Inganäs, Pål Møller "— Presentation transcript:

1 Penetrances of BRCA1 1675delA and 1135insA with Respect to Breast Cancer and Ovarian Cancer 
Anne Dørum, Ketil Heimdal, Eivind Hovig, Mats Inganäs, Pål Møller  The American Journal of Human Genetics  Volume 65, Issue 3, Pages (September 1999) DOI: /302530 Copyright © 1999 The American Society of Human Genetics Terms and Conditions

2 Figure 1 Age-related penetrances of BRCA1 1675delA (thicker line) and 1135insA (thinner line) in mutation carriers (demonstrated, affected, or obligate). Index cases are not included. a, Breast and/or ovarian cancer (whichever came first) scored as event. b, Ovarian cancer scored as event (breast cancer considered as unaffected). c, Breast cancer scored as event (ovarian cancer considered as unaffected). The American Journal of Human Genetics  , DOI: ( /302530) Copyright © 1999 The American Society of Human Genetics Terms and Conditions

3 Figure 2 Age-related penetrances of BRCA1 1675delA and 1135insA in mutation carriers (demonstrated, affected, or obligate). Consecutive ovarian-cancer series (thicker line) and family cancer-clinic series (thinner line). Index cases are not included. a, Breast and/or ovarian cancer (whichever came first) scored as event. b, Ovarian cancer scored as event (breast cancer considered as unaffected). c, Breast cancer scored as event (ovarian cancer considered as unaffected). The American Journal of Human Genetics  , DOI: ( /302530) Copyright © 1999 The American Society of Human Genetics Terms and Conditions

4 Figure 3 Age-related penetrance in the combined series, including demonstrated mutation carriers and obligate carriers only, with index cases excluded. The American Journal of Human Genetics  , DOI: ( /302530) Copyright © 1999 The American Society of Human Genetics Terms and Conditions

5 Figure 4 Age-related penetrances of BRCA1 1675delA and 1135insA in the consecutive ovarian-cancer series. Only mutation carriers (demonstrated, affected, or obligate) are included; index cases are excluded. a, Ovarian cancer scored as event (patients with breast cancer censored at age at diagnosis). b, Breast cancer scored as event (patients with ovarian cancer censored at age at diagnosis). The American Journal of Human Genetics  , DOI: ( /302530) Copyright © 1999 The American Society of Human Genetics Terms and Conditions

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