1. Development of New Reactions Based on Decarboxylative Metalation
Jon A. Tunge, Department of Chemistry, The University of Kansas, Lawrence, KS
Decarboxylative Coupling: Catalytic cross-coupling reactions have made a significant positive impact in the synthesis of chemically-complex small molecules that are essential to development of therapeutics. Such reactions typically involve the use of relatively expensive, toxic, or highly basic reagents. In addition, the reagents required for transmetalation necessarily produce stoichiometric quantities of hazardous byproducts. With this in mind, we are developing reactions that utilize inexpensive substrates, proceed under mild conditions, and are environmentally benign. These “green” cross-coupling reactions capitalize on CO2 release as a driving force for the formation of reactive species under mild, neutral conditions