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Transferring Death: A Role for tRNA in Apoptosis Regulation

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Presentation on theme: "Transferring Death: A Role for tRNA in Apoptosis Regulation"— Presentation transcript:

1 Transferring Death: A Role for tRNA in Apoptosis Regulation
Bram J. van Raam, Guy S. Salvesen  Molecular Cell  Volume 37, Issue 5, Pages (March 2010) DOI: /j.molcel Copyright © 2010 Elsevier Inc. Terms and Conditions

2 Figure 1 Components of the Commitment Phase of Apoptosis
Mitochondria release cytochrome c, which activates Apaf-1 to generate an oligomeric platform known as the apoptosome capable of activating caspase-9. The process is negatively regulated by direct inhibition of caspase-9 by XIAP. Wei et al. now show that cytochrome c is itself sequestered by tRNAs, providing an additional control mechanism. Molecular Cell  , DOI: ( /j.molcel ) Copyright © 2010 Elsevier Inc. Terms and Conditions

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