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Dense mapping of chromosome 12q q23

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1 Dense mapping of chromosome 12q13. 12-q23
Dense mapping of chromosome 12q13.12-q23.3 and linkage to asthma and atopy  Kathleen C. Barnes, PhDa, Linda R. Freidhoff, MSa, Renate Nickel, MDa, Yen-Feng Chiu, MSb,c, Suh-Hang Juo, PhDc,d, Nobuyuki Hizawa, MDa,e, Raana P. Naidu, MDf, Eva Ehrlich, MSa, David L. Duffy, PhDc,g, Carsten Schou, PhDh, Paul N. Levett, PhDf, David G. Marsh, PhDa,†, Terri H. Beaty, PhDc  Journal of Allergy and Clinical Immunology  Volume 104, Issue 2, Pages (August 1999) DOI: /S (99) Copyright © 1999 Mosby, Inc. Terms and Conditions

2 Fig. 1 Linkage map of human chromosome 12q13.12-q23.3 based on a sex-averaged linkage map of the 22 markers analyzed with the CRIMAP 2.4 Kosambi mapping function.38 The map includes the following genes: STAT6 , IFNG , B-cell translocation gene 1 (BTG1 ), stem cell factor (SCF ), leukotriene A(4) hydrolase (LTA4H ), insulin-like growth factor-1 (IGF1 ), phenylalanine hydroxylase (PAH ); and the β-subunit of nuclear factor-Y (NFYB ). Physical distances of the genes in relation to the markers are approximate based on data obtained from Journal of Allergy and Clinical Immunology  , DOI: ( /S (99) ) Copyright © 1999 Mosby, Inc. Terms and Conditions

3 Fig. 2 Multipoint IBD affected relative analysis of chromosome 12q markers in 33 Barbadian kindreds for asthma (A) and allergic rhinitis (B) . The x axis illustrates the map positions of the markers by using the Kosambi mapping function for both CRIMAP and GENEHUNTER (Version 1.0;40 under the “fixed” option and the locus order indicated by the physical map of Krauter et al7), and the y axis is the NPL score. The horizontal, small-hatched line indicates level of significance (P < .05). Journal of Allergy and Clinical Immunology  , DOI: ( /S (99) ) Copyright © 1999 Mosby, Inc. Terms and Conditions


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