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Population Pharmacokinetic Modeling of Thymoglobulin in Children Receiving Allogeneic-Hematopoietic Cell Transplantation (HCT): Towards Individualized Dosing to Improve Survival R. Admiraal, MD, Charlotte van Kesteren, PharmD, PhD, Cornelia M. Jol-van der Zijde, Maarten van Tol, PhD, Imke Bartelink, PharmD, PhD, Robbert Bredius, MD, PhD, Jaap-Jan Boelens, MD, PhD, Catherijne A.J. Knibbe, PharmD, PhD Biology of Blood and Marrow Transplantation Volume 20, Issue 2, Pages S96-S98 (February 2014) DOI: /j.bbmt Copyright © Terms and Conditions
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Fig 1 Observed concentrations (black dots) and individual predictions (red lines) of active Thymoglobulin versus time for representative individuals in different body weight groups. Biology of Blood and Marrow Transplantation , S96-S98DOI: ( /j.bbmt ) Copyright © Terms and Conditions
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Figure 2 Observed versus individual predicted concentrations of active Thymoglobulin in all patients split by age. Dots: logtransformed observations, lines: line of unity (x=y). Biology of Blood and Marrow Transplantation , S96-S98DOI: ( /j.bbmt ) Copyright © Terms and Conditions
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Figure 3 Median (red line) and 95% confidence interval (blue lines) active Thymoglobulin concentrations versus time in patients with a bodyweight of 5, 20, 40 and 60 kg after a cumulative dose of 10 mg/kg given over four days. (Color version of figure is available online at Biology of Blood and Marrow Transplantation , S96-S98DOI: ( /j.bbmt ) Copyright © Terms and Conditions
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