1. Figure 1 Tau promotes neuronal hypoactivity, even in the absence of tangles. (A) Schematic of the experimental ...
Figure 1 Tau promotes neuronal hypoactivity, even in the absence of tangles. (A) Schematic of the experimental approach of Marinković et al., which combined injection of tau fibrils into the cortex of tau-overexpressing P301S mice with in vivo multiphoton GCaMP6s calcium imaging. Tangle-bearing mice (right panel in B and C) were compared to wild-type mice (left) and P301S mice injected with buffer (middle). (B) Spontaneous activity of layer 2/3 cortical neurons is suppressed (indicated by blue colour) in tau overexpressing P301S mice with and without tangles (middle and right). Further analysis did not detect differences in the activity status of tangle-bearing and tangle-free neurons (right). (C) Neuronal activity status remained unchanged over a 10-week recording period.
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Brain, Volume 142, Issue 4, 29 March 2019, Pages 843–846,
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