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Experimental and numeric investigation of Impella pumps as cavopulmonary assistance for a failing Fontan  Christopher M. Haggerty, BS, Francis Fynn-Thompson,

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Presentation on theme: "Experimental and numeric investigation of Impella pumps as cavopulmonary assistance for a failing Fontan  Christopher M. Haggerty, BS, Francis Fynn-Thompson,"— Presentation transcript:

1 Experimental and numeric investigation of Impella pumps as cavopulmonary assistance for a failing Fontan  Christopher M. Haggerty, BS, Francis Fynn-Thompson, MD, Doff B. McElhinney, MD, Anne Marie Valente, MD, Neelakantan Saikrishnan, PhD, Pedro J. del Nido, MD, Ajit P. Yoganathan, PhD  The Journal of Thoracic and Cardiovascular Surgery  Volume 144, Issue 3, Pages (September 2012) DOI: /j.jtcvs Copyright © 2012 The American Association for Thoracic Surgery Terms and Conditions

2 Figure 1 Details of experimental setup. A, Schematic of mock circulatory loop. B, Anterior and superior views of computer-aided design model for patient-specific TCPC used in experimental setup. C, The 3 microaxial devices used in the study are 2.5, 5.0, and RP (left to right). Arrows denote position of the motor and direction of flow. D, Positioning of deployed 5.0 device with respect to TCPC model. E, Positioning of the RP device with respect to TCPC model. LA, Left atrium; SV, superior vein; IV, inferior vein; PVR, pulmonary vascular resistance; TCPC, total cavopulmonary connection; RPA, right pulmonary artery; SVC, superior vena cava; LPA, left pulmonary artery; IVC, inferior vena cava. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2012 The American Association for Thoracic Surgery Terms and Conditions

3 Figure 2 Detailed experimental results for the RP device showing the responses of (A, B) LPA pressure (at different baseline CVP values), LPA flow (C), and flow recirculation (D) as functions of pump speed (horizontal axes) and PVR (column colors). LPA, Left pulmonary artery; CVP, central venous pressure; PVR, pulmonary vascular resistance; PLPA, left pulmonary artery pressure; QLPA, left pulmonary artery flow. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2012 The American Association for Thoracic Surgery Terms and Conditions

4 Figure 3 Summary of lumped parameter modeling for RP configuration in TCPC. A, Ventricular pressure-volume relationships with increasing pump speed. Changes in vessel (B) flow rates and (C) pressures as a function of pump speed with all other parameters unchanged. D, Pressure response for each TCPC vessel as a function of decreasing LPA resistance (R, in mm Hg · min/L). E, Changes in cardiac output, RPA flow, and IVC pressure in response to increased systemic venous compliance. RPA, Right pulmonary artery; IVC, inferior vena cava; SV, single ventricle; SVC, superior vena cava; LPA, left pulmonary artery; AO, aorta; RPM, revolutions per minute. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2012 The American Association for Thoracic Surgery Terms and Conditions


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