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Need for Speed: Mechanical Regulation of a Replicative Helicase

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Presentation on theme: "Need for Speed: Mechanical Regulation of a Replicative Helicase"— Presentation transcript:

1 Need for Speed: Mechanical Regulation of a Replicative Helicase
Taekjip Ha  Cell  Volume 129, Issue 7, Pages (June 2007) DOI: /j.cell Copyright © 2007 Elsevier Inc. Terms and Conditions

2 Figure 1 How Helicases Speed Up
(A) A hexameric helicase moves on the lagging strand in the 5′ to 3′ direction and unwinds the double-stranded DNA ahead. Its unwinding speed is much lower than its intrinsic translocation speed, possibly due to an inhibitory interaction between the helicase and the opposing strand. When a force is applied on the DNA strands (B) or when a DNA polymerase reaction is coupled with unwinding (C), the unwinding speed is dramatically enhanced. Therefore, regulation of helicase activities by other proteins may be mechanical in origin. Cell  , DOI: ( /j.cell ) Copyright © 2007 Elsevier Inc. Terms and Conditions

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