1. Control of Smad7 stability by competition between Acetylation and Ubiquitination
Gronroos et al., 2002, Mol Cell

2. TGFb signaling
Peter ten Dijke and Caroline S. Hill, 2004, TRENDS in Biochemical Sciences.

3. Smad7 (Smad antagonist)
1, 2, 3, 5, 8
6, 7
Smad7 blocks Smad signaling by inhibiting Smad phosphorylation and by recruiting a Smurf2 to degrade the type 1 receptors of TGFb and/or Smads.

4. HAT families and functional motifs
Roth et al., 2001, Annu. Rev. Biochem.

5. Ramifications of acetylation of non-histone cellular proteins
Glozak et al., 2005, Gene

6. Fig. 1) Smad7 interacts with the coactivator p300

7. Fig. 2) Smad7 is a substrate for p300 in vivo

8. Fig. 3) Lysine residues 64 and 70 in Smad7 are targeted by p300-mediated acetylation

9. Fig. 4) p300 acetylates specific lysine residues in Smad7

11. Fig. 5) Acetylation of Smad7 protects it from caALK5-induced degradation

14. Fig. 6) The acetylated lysine residues in Smad7 control its stability

15. Fig. 7) Inhibition of p300 negatively affects the acetylation and stability of Smad7

16. Fig. 8) Acetylation of Smad7 protects it from Smurf1-induced degradation

17. Three major mechanisms involved in the control of protein stability following lysine acetylation
Caron et al., 2005, BioEssays