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Exogenous adrenomedullin prevents and reverses hypodynamic circulation and pulmonary hypertension in ovine endotoxaemia  C. Ertmer, A. Morelli, S. Rehberg,

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Presentation on theme: "Exogenous adrenomedullin prevents and reverses hypodynamic circulation and pulmonary hypertension in ovine endotoxaemia  C. Ertmer, A. Morelli, S. Rehberg,"— Presentation transcript:

1 Exogenous adrenomedullin prevents and reverses hypodynamic circulation and pulmonary hypertension in ovine endotoxaemia  C. Ertmer, A. Morelli, S. Rehberg, M. Lange, C. Hucklenbruch, H. Van Aken, M. Booke, M. Westphal  British Journal of Anaesthesia  Volume 99, Issue 6, Pages (December 2007) DOI: /bja/aem295 Copyright © 2007 British Journal of Anaesthesia Terms and Conditions

2 Fig 1 Schematic diagram of the study design. ADM, adrenomedullin; BL, baseline. British Journal of Anaesthesia  , DOI: ( /bja/aem295) Copyright © 2007 British Journal of Anaesthesia Terms and Conditions

3 Fig 2 Changes in systemic and pulmonary variables in endotoxaemic sheep treated with prophylactic or therapeutic adrenomedullin. BL, baseline; CI, cardiac index; HR, heart rate; MAP, mean arterial pressure; MPAP, mean pulmonary arterial pressure; PVRI, pulmonary vascular resistance index; SVRI, systemic vascular resistance index; *P < 0.05 prophylaxis vs control; †P < 0.05 treatment vs control. British Journal of Anaesthesia  , DOI: ( /bja/aem295) Copyright © 2007 British Journal of Anaesthesia Terms and Conditions

4 Fig 3 Changes in oxygen delivery index (DO2I), oxygen extraction rate (O2-ER), and plasma lactate concentrations in sheep treated with prophylactic or therapeutic adrenomedullin. BL, baseline; *P < 0.05 prophylaxis vs control; †P < 0.05 treatment vs control. British Journal of Anaesthesia  , DOI: ( /bja/aem295) Copyright © 2007 British Journal of Anaesthesia Terms and Conditions

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