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Regulating the Timing of CENP-A Nucleosome Assembly by Phosphorylation

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Presentation on theme: "Regulating the Timing of CENP-A Nucleosome Assembly by Phosphorylation"— Presentation transcript:

1 Regulating the Timing of CENP-A Nucleosome Assembly by Phosphorylation
Matthew D.D. Miell, Aaron F. Straight  Developmental Cell  Volume 32, Issue 1, Pages 1-2 (January 2015) DOI: /j.devcel Copyright © 2015 Elsevier Inc. Terms and Conditions

2 Figure 1 A Model for the Regulation of CENP-A Assembly
CDK and Plk1 act as master regulators of CENP-A assembly timing. Plk1 phosphorylation of Mis18BP1 enables its recruitment to centromeres early in mitosis through an interaction with CENP-C. CDK activity during G2 and mitosis phosphorylates CENP-A and HJURP, preventing their association until CDK activity drops during anaphase. CDK activity also prevents the association of Mis18α/β with Mis18BP1. As CDK activity drops in late mitosis, HJURP, CENP-A, and H4 are recruited to centromeres through an interaction between Mis18β and HJURP that enables incorporation of CENP-A and H4 into nucleosomes. Developmental Cell  , 1-2DOI: ( /j.devcel ) Copyright © 2015 Elsevier Inc. Terms and Conditions

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