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Volume 381, Issue 9880, Pages (May 2013)

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Presentation on theme: "Volume 381, Issue 9880, Pages (May 2013)"— Presentation transcript:

1 Volume 381, Issue 9880, Pages 1817-1826 (May 2013)
Rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisolone in patients with newly diagnosed diffuse large B-cell non-Hodgkin lymphoma: a phase 3 comparison of dose intensification with 14-day versus 21-day cycles  Prof David Cunningham, FMedSci, Eliza A Hawkes, FRACP, Andrew Jack, PhD, Wendi Qian, PhD, Paul Smith, MSc, Paul Mouncey, MSc, Christopher Pocock, PhD, Kirit M Ardeshna, FRCPath, Prof John A Radford, MD, Andrew McMillan, FRCPath, John Davies, FRCPE, Deborah Turner, FRCPath, Anton Kruger, FRCPath, Prof Peter Johnson, FRCP, Joanna Gambell, BSc, Prof David Linch, FMedSci  The Lancet  Volume 381, Issue 9880, Pages (May 2013) DOI: /S (13)60313-X Copyright © 2013 Elsevier Ltd Terms and Conditions

2 Figure 1 Trial profile R-CHOP-21=cycles of rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisolone every 21 days. R-CHOP-14=cycles of rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisolone every 14 days. LVEF=left ventricular ejection fraction. *Includes 35 people who did not have an end-of-treatment scan and therefore were not assessable for end-of-treatment response. † Includes 34 people who did not have an end-of-treatment scan and therefore were not assessable for end-of-treatment response. The Lancet  , DOI: ( /S (13)60313-X) Copyright © 2013 Elsevier Ltd Terms and Conditions

3 Figure 2 Progression-free survival (A) and overall survival (B) according to treatment R-CHOP-14=cycles of rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisolone every 14 days. R-CHOP-21=cycles of rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisolone every 21 days. The Lancet  , DOI: ( /S (13)60313-X) Copyright © 2013 Elsevier Ltd Terms and Conditions

4 Figure 3 Analysis of prognostic factors for overall survival
Data are number, unless otherwise indicated. R-CHOP-14=cycles of rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisolone every 14 days. R-CHOP-21=cycles of rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisolone every 21 days. df=degrees of freedom. The Lancet  , DOI: ( /S (13)60313-X) Copyright © 2013 Elsevier Ltd Terms and Conditions

5 Figure 4 Analysis of prognostic factors for progression-free survival
Data are number, unless otherwise indicated. R-CHOP-14=cycles of rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisolone every 14 days. R-CHOP-21=cycles of rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisolone every 21 days. df=degrees of freedom. The Lancet  , DOI: ( /S (13)60313-X) Copyright © 2013 Elsevier Ltd Terms and Conditions


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