1. Global vs Local Alignment
Jasmin sutkovic – Bioinformatics Lab 3

2. What is the difference?

3. Global Alignment
Compare the whole sequence, from one end to another, with our query sequence in order to find the best overall alignment

4. Local Alignment
Compare only parts of the sequence with our query in order to get the best local alignments

5. Examples of Algorithms
Global alignment:
Needleman-Wunsch
Local alignment:
Smith-Waterman

6. Example

7. When do we use one and when the other?

8. Global Aligment When we want to compare the whole sequences or genes
Usually when we are working with homologus genes

9. Local Alignment
When we want to compare only parts of sequences or genes
Usually when we are working with nonhomologus genes
When we want to find the same/simillar protein domains in different genes

17. Thank you for your attenuation 