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Volume 383, Issue 9922, Pages (March 2014)

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Presentation on theme: "Volume 383, Issue 9922, Pages (March 2014)"— Presentation transcript:

1 Volume 383, Issue 9922, Pages 1041-1048 (March 2014)
Anastrozole for prevention of breast cancer in high-risk postmenopausal women (IBIS- II): an international, double-blind, randomised placebo-controlled trial  Prof Jack Cuzick, PhD, Ivana Sestak, PhD, Prof John F Forbes, MD, Prof Mitch Dowsett, PhD, Jill Knox, MSc, Simon Cawthorn, MD, Prof Christobel Saunders, MD, Nicola Roche, MD, Prof Robert E Mansel, MD, Gunter von Minckwitz, MD, Bernardo Bonanni, MD, Tiina Palva, MD, Prof Anthony Howell, MD  The Lancet  Volume 383, Issue 9922, Pages (March 2014) DOI: /S (13) Copyright © 2014 Cuzick et al. Open Access article distributed under the terms of CC BY Terms and Conditions

2 Figure 1 Trial profile ER=oestrogen receptor. *Could not give family history to establish whether high risk. The Lancet  , DOI: ( /S (13) ) Copyright © 2014 Cuzick et al. Open Access article distributed under the terms of CC BY Terms and Conditions

3 Figure 2 Analyses by type of breast cancer
Numbers in subgroups do not match totals because of missing data. ER=oestrogen receptor. The Lancet  , DOI: ( /S (13) ) Copyright © 2014 Cuzick et al. Open Access article distributed under the terms of CC BY Terms and Conditions

4 Figure 3 Cumulative incidence of all breast cancers and of invasive ER-positive breast cancers ER=oestrogen receptor. The Lancet  , DOI: ( /S (13) ) Copyright © 2014 Cuzick et al. Open Access article distributed under the terms of CC BY Terms and Conditions

5 Figure 4 Analyses by invasive breast cancer characteristics
Numbers in subgroups do not match totals because of missing data. *Assessed at local laboratories. The Lancet  , DOI: ( /S (13) ) Copyright © 2014 Cuzick et al. Open Access article distributed under the terms of CC BY Terms and Conditions

6 Figure 5 Subgroup comparisons
*Cumulative risk calculated with Cox proportional hazards model. The Lancet  , DOI: ( /S (13) ) Copyright © 2014 Cuzick et al. Open Access article distributed under the terms of CC BY Terms and Conditions


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