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Impact on Disease-Free Survival of Adjuvant Erlotinib or Gefitinib in Patients with Resected Lung Adenocarcinomas that Harbor EGFR Mutations  Yelena Y.

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Presentation on theme: "Impact on Disease-Free Survival of Adjuvant Erlotinib or Gefitinib in Patients with Resected Lung Adenocarcinomas that Harbor EGFR Mutations  Yelena Y."— Presentation transcript:

1 Impact on Disease-Free Survival of Adjuvant Erlotinib or Gefitinib in Patients with Resected Lung Adenocarcinomas that Harbor EGFR Mutations  Yelena Y. Janjigian, MD, Bernard J. Park, MD, Maureen F. Zakowski, MD, Marc Ladanyi, MD, William Pao, MD, PhD, Sandra P. D'Angelo, MD, Mark G. Kris, MD, Ronglai Shen, PhD, Junting Zheng, MS, Christopher G. Azzoli, MD  Journal of Thoracic Oncology  Volume 6, Issue 3, Pages (March 2011) DOI: /JTO.0b013e318202bffe Copyright © 2011 International Association for the Study of Lung Cancer Terms and Conditions

2 FIGURE 1 Kaplan-Meier curves for survival. Kaplan-Meier curves for disease-free survival (panel A) and for overall survival (panel B) by gefitinib/erlotinib therapy. G/E denotes gefitinib/erlotinib. *Hazard ratios were calculated with the use of a Cox proportional hazards model, with the type of surgery, stage, cisplatin chemotherapy, and sex as covariates and gefitinib/erlotinib therapy as time-dependent factor; Cox proportional hazards model with gefitinib/erlotinib therapy as time-dependent factor. With respect to the disease-free survival and overall survival, results of a log-rank test, p = (panel A) and p = (panel B). Journal of Thoracic Oncology 2011 6, DOI: ( /JTO.0b013e318202bffe) Copyright © 2011 International Association for the Study of Lung Cancer Terms and Conditions

3 FIGURE 2 Schema for a clinical trial of adjuvant erlotinib or gefitinib. Primary end point is disease-free survival proportion at 2 years from time of randomization. EGFR, epidermal growth factor receptor. Journal of Thoracic Oncology 2011 6, DOI: ( /JTO.0b013e318202bffe) Copyright © 2011 International Association for the Study of Lung Cancer Terms and Conditions

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