1. Intraoperative naloxone reduces remifentanil-induced postoperative hyperalgesia but not pain: a randomized controlled trial 
C.-H. Koo, S. Yoon, B.-R. Kim, Y.J. Cho, T.K. Kim, Y. Jeon, J.-H. Seo 
British Journal of Anaesthesia 
Volume 119, Issue 6, Pages (December 2017)
DOI: /bja/aex253
Copyright © 2017 The Author(s) Terms and Conditions

2. Fig 1
CONSORT diagram.
British Journal of Anaesthesia  , DOI: ( /bja/aex253)
Copyright © 2017 The Author(s) Terms and Conditions

3. Fig 2
Mean blood pressure (A) and heart rate (B) during anaesthesia. Data are mean and sd. *Mean difference (95% CI) 20 (5–35) mm Hg, P=0.008 and 19 (5–34) mm Hg, P=0.010 compared with the high-remifentanil with and without naloxone groups, respectively, by unpaired t-test; †14 (5–24) mm Hg, P=0.005 and 17 (8–26) mm Hg, P<0.001; ‡10 (1–20) beats min−1, P=0.043 and 15 (5–25) beats min−1, P=0.003; §14 (5–24) beats min−1, P=0.001 and 14 (4–26) beats min−1, P=0.002.
British Journal of Anaesthesia  , DOI: ( /bja/aex253)
Copyright © 2017 The Author(s) Terms and Conditions

4. Fig 3
Pain thresholds to mechanical stimuli presented as von Frey numbers on the peri-incisional area of thyroid surgery (A) and the forearm (B). P=0.007 (*), (†) and (‡) by Mann–Whitney U-test.
British Journal of Anaesthesia  , DOI: ( /bja/aex253)
Copyright © 2017 The Author(s) Terms and Conditions

5. Fig 4
Postoperative pain intensity assessed by an 11-point numeric rating scale (0, no pain; 10, worst pain imaginable). Data are mean and sd. There were no significant differences between groups [P=0.23 by repeated-measures analysis of variance (ANOVA)].
British Journal of Anaesthesia  , DOI: ( /bja/aex253)
Copyright © 2017 The Author(s) Terms and Conditions