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Baby Nuclear Pores Grow Up Faster All the Time

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Presentation on theme: "Baby Nuclear Pores Grow Up Faster All the Time"— Presentation transcript:

1 Baby Nuclear Pores Grow Up Faster All the Time
C. Patrick Lusk  Cell  Volume 166, Issue 3, Pages (July 2016) DOI: /j.cell Copyright © 2016 Elsevier Inc. Terms and Conditions

2 Figure 1 Insertion of Annulate Lamellae into the Nuclear Envelope
(A) Annulate lamellae (AL) contain NPC skeletons lacking the full complement of nucleoporins (nups) that are embedded in stacked ER membranes. They are directly connected to the NE around large fenestrations. The NPC skeletons have nups capable of establishing a diffusion barrier to large macromolecules and are unlikely to mediate active nuclear transport of nuclear transport receptor (NTR) cargo complexes. (B) During rapid NE expansion in interphase, the AL are incorporated into the NE as NPC skeletons mature to complete NPC assembly. INM and ONM, inner and outer nuclear membrane, respectively. Cell  , DOI: ( /j.cell ) Copyright © 2016 Elsevier Inc. Terms and Conditions


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