1. Results of ASERTAA, a Randomized Prospective Crossover Pharmacogenetic Study of Immediate-Release Versus Extended-Release Tacrolimus in African American Kidney Transplant Recipients 
Jennifer Trofe-Clark, Daniel C. Brennan, Patricia West-Thielke, Michael C. Milone, Mary Ann Lim, Robin Neubauer, Vincenza Nigro, Roy D. Bloom 
American Journal of Kidney Diseases 
Volume 71, Issue 3, Pages (March 2018)
DOI: /j.ajkd
Copyright © 2017 The Authors Terms and Conditions

2. Figure 1
Study design. Abbreviations and definitions: IR-Tac, immediate-release tacrolimus; LCPT, extended-released tacrolimus (originally LifeCycle Pharma Tacrolimus); PK, pharmacokinetic.
American Journal of Kidney Diseases  , DOI: ( /j.ajkd )
Copyright © 2017 The Authors Terms and Conditions

3. Figure 2
Patient attrition flow diagram. Abbreviations and definitions: IR-Tac, immediate-release tacrolimus; LCPT, extended-release tacrolimus (originally LifeCycle Pharma Tacrolimus); LFT, liver function test; PK, pharmacokinetic.
American Journal of Kidney Diseases  , DOI: ( /j.ajkd )
Copyright © 2017 The Authors Terms and Conditions

4. Figure 3
Observed mean tacrolimus whole blood time-concentration curves for immediate-release tacrolimus (IR-Tac) and LCPT (extended-release tacrolimus; originally LifeCycle Pharma Tacrolimus). Abbreviations: AUC, area under the curve; SE, standard error; TDD, total daily dose.
American Journal of Kidney Diseases  , DOI: ( /j.ajkd )
Copyright © 2017 The Authors Terms and Conditions

5. Figure 4 Tacrolimus total daily dose (TDD) by CYP3A5 genotype.
American Journal of Kidney Diseases  , DOI: ( /j.ajkd )
Copyright © 2017 The Authors Terms and Conditions

6. Figure 5
Observed mean tacrolimus whole blood time-concentration curves by CYP3A5 expresser status for (A) immediate-release tacrolimus (IR-Tac) and (B) LCPT (extended-release tacrolimus; originally LifeCycle Pharma Tacrolimus). Abbreviations: AUC0-24, area under the concentration-time curve from time 0 to 24 hours; Cmax, maximum observed concentration, peak; SE, standard error; TDD, total daily dose.
American Journal of Kidney Diseases  , DOI: ( /j.ajkd )
Copyright © 2017 The Authors Terms and Conditions