1. Quantitative MR T2 measurement of articular cartilage to assess the treatment effect of intra-articular hyaluronic acid injection on experimental osteoarthritis induced by ACLX 
G.-S. Huang, H.-S. Lee, M.-C. Chou, Y.-Y.I. Shih, P.-H. Tsai, M.-H. Lin, C.-Y. Lin, C.-H. Lee, H.-W. Chung 
Osteoarthritis and Cartilage 
Volume 18, Issue 1, Pages (January 2010)
DOI: /j.joca
Copyright © 2009 Osteoarthritis Research Society International Terms and Conditions

2. Fig. 1
The protocol designs for the ACLX+NS, ACLX+HA, and sham-control groups. Time scale: ( ) OA development, ( ) treatment, ( □ ) observation, ( ) MRI T2 experiment, ( ) Mankin score analysis.
Osteoarthritis and Cartilage  , 54-60DOI: ( /j.joca )
Copyright © 2009 Osteoarthritis Research Society International Terms and Conditions

3. Fig. 2
Prescription for the 14 slices for the T2 experiments in the axial (a) and coronal (b) planes. The three slices were placed parallel to each of the medial and lateral femorotibial condyles, and two single slices were located on the middle lines of the knee joints.
Osteoarthritis and Cartilage  , 54-60DOI: ( /j.joca )
Copyright © 2009 Osteoarthritis Research Society International Terms and Conditions

4. Fig. 3
Plots of cartilage T2 (mean±SD) measured at weeks 0, 4, and 13 in the ACLX+NS (a) ACLX+HA (b) and sham-control (c) groups. Cartilage T2 was measured separately in the operated right knee and the untouched left knee of all rats. Asterisks indicate significant differences (P<0.05).
Osteoarthritis and Cartilage  , 54-60DOI: ( /j.joca )
Copyright © 2009 Osteoarthritis Research Society International Terms and Conditions

5. Fig. 4
Histological features of articular cartilage. (a) The articular cartilage from the sham-control rats showed normal histology with a smooth cartilage surface and regular arrangement of the chondrocytes. (b) Experimentally induced cartilage degeneration with fibrillation, cleft formation, and matrix degeneration in the ACLX+NS rats was identified clearly. (c) The articular cartilage from the ACLX+HA rats demonstrated mildly rough surface and focal matrix degeneration. The degeneration severity in the ACLX+HA rats is less than that seen in the ACLX+NS rats. (H&E, 400×)
Osteoarthritis and Cartilage  , 54-60DOI: ( /j.joca )
Copyright © 2009 Osteoarthritis Research Society International Terms and Conditions

6. Fig. 5
The distribution and correlation of T2 values (ms) and Mankin scores (points) of the ACLX+NS (diamonds), ACLX+HA (squares), and sham-control (triangles) rats in this study. Each symbol represents one data point obtained from one knee joint. Solid and hollow symbols indicate the operated right and the untouched left knee cartilage, respectively. Significant positive correlations between the T2 values and Mankin scores were found in the ACLX+NS and ACLX+HA groups.
Osteoarthritis and Cartilage  , 54-60DOI: ( /j.joca )
Copyright © 2009 Osteoarthritis Research Society International Terms and Conditions