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Inositol Pyrophosphates Get the Vip1 Treatment
Sara Maria Nancy Onnebo, Adolfo Saiardi Cell Volume 129, Issue 4, Pages (May 2007) DOI: /j.cell Copyright © 2007 Elsevier Inc. Terms and Conditions
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Figure 1 The Biosynthetic Pathway of Inositol Pyrophosphates
Myo-inositol (shown with six hydroxyl groups: five equatorial and one axial at position C2) is the building block of inositol polyphosphates. Sequential kinase reactions convert IP3 to IP4, IP5, and IP6. The fully phosphorylated ring is then converted to IP7 either by the action of the inositol pyrophosphate synthase Kcs1, generating the isomer 5PP-IP4, or by the newly identified enzyme Vip1, generating 4/6PP-IP4. Cell , DOI: ( /j.cell ) Copyright © 2007 Elsevier Inc. Terms and Conditions
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