1. Animal Models of Melanoma
Linan Ha, Frances P. Noonan, Edward C. De Fabo, Glenn Merlino 
Journal of Investigative Dermatology Symposium Proceedings 
Volume 10, Issue 2, Pages (November 2005)
DOI: /j x
Copyright © 2005 The Society for Investigative Dermatology, Inc Terms and Conditions

2. Figure 1
Histopathological comparison between a panel of human melanomas (left), and melanocytic lesions arising in ultraviolet (UV)-irradiated hepatocyte growth factor/scatter factor (HGF/SF)-transgenic mice (right). (a) Early human melanoma in situ in which solitary atypical melanocytes (arrow) are scattered into the upper epidermis. (b) Lesion arising in HGF/SF-transgenic mouse with same features shown in (a) (arrow). Inset: Identification of scattered epidermal cells as melanocytes (TRP1 positive). (c) Two panels showing more advanced human radial growth phase melanoma exhibiting proliferation of atypical melanocytes as solitary units (arrowhead) or nests (arrow), distributed along and above the dermal–epithelial junction. (d) Two lesions arising in HGF/SF-transgenic mice highly similar to (c) showing large nests of atypical melanocytes (arrow), and “pagetoid spread” melanoma cells into the keratinized layer (arrowhead). Inset: Identification of nested cells as melanocytes (TRP1 positive). (e) Representative human vertical growth phase melanoma exhibiting broad growth, asymmetry, and irregular distribution of melanocytes along the junction; lower magnification. (f) Invasive lesion from transgenic mice comparable with (e) exhibiting broad growth, asymmetry, and chaotic melanocyte distribution in the epidermis; lower magnification. Inset displays S100 stain of same tumor. (g) Lymph node metastasis from melanoma patient. Inset: Lower magnification of S100-positive metastatic cells. (h) Lymph node metastasis from UV-irradiated transgenic mouse. Inset: lower magnification of TRP1-positive metastatic cells. All tissue sections shown were stained with H&E unless otherwise indicated. This figure is reproduced fromRecio et al (2002), with permission from the American Association of Cancer Research.
Journal of Investigative Dermatology Symposium Proceedings  , 86-88DOI: ( /j x)
Copyright © 2005 The Society for Investigative Dermatology, Inc Terms and Conditions

3. Figure 2
Melanoma induction in neonatally ultraviolet (UV)-irradiated albino hepatocyte growth factor/scatter factor (HGF/SF)-transgenic mice. Shown are the Kaplan–Meier melanoma-free survival curves for HGF/SF-transgenic mice treated with pure UVA (black) or pure UVB (red). Note that UVA exposure in these mice was alone, incapable of inducing melanoma genesis; seeDe Fabo et al (2004) for details.
Journal of Investigative Dermatology Symposium Proceedings  , 86-88DOI: ( /j x)
Copyright © 2005 The Society for Investigative Dermatology, Inc Terms and Conditions