1. Changes in clinical disease activity over 24 months on a continuous scale in SWEFOT trial participants randomised to triple therapy or anti-TNF with available baseline BMI categories.
Changes in clinical disease activity over 24 months on a continuous scale in SWEFOT trial participants randomised to triple therapy or anti-TNF with available baseline BMI categories. Patients not achieving low disease activity (DAS28 <3.2) at the 3-month follow-up visit were randomised, and the EULAR good response at 24 months of follow-up was calculated using randomisation at 3 months as the baseline value. Individual time points with DAS28 over 24 months are plotted with medians and IQR. Included among all patients (A) is the combination of the two randomised groups, triple therapy (B), n=94 or anti-TNF (C), n=91. Responders to methotrexate (DAS28 ≤3.2) continued on monotherapy and are not included due to non-randomisation. Sample size (n) for normal weight, overweight and obese in (A): 103, 48, 32; (B): 52, 22, 20; and (C): 53, 26, 12, respectively. Obese versus normal weight: *p<0.05; **p≤0.002. BMI, body mass index; EULAR, European League Against Rheumatism; m, months; SWEFOT, Swedish Pharmacotherapy Trial; TNF, tumour necrosis factor.
Adrian Levitsky et al. RMD Open 2017;3:e000458
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