1. Fundamentals of Multiscale Fabrication Micro- and nanofluidics
Lecture 11
Applications III:
Micro- and nanofluidics
Kahp-Yang Suh
Associate Professor
SNU MAE

2. What is Microfluidics?
Microfluidics is a technology which refers to the research and development of micro-scale devices which handle small volumes of fluids (as small as micro-, nano-, pico- and even femtoliter volumes).
The devices have dimensions ranging from several millimeters to micrometers ~ the miniaturization of the entire system is not a requirement.
Materials for microfluidics
Fabrication of microfluidics
Microfluidic components

3. Micro-/nanofluidics
► Micro/nanofluidics aims at investigating and developing miniature device which sense, pump, mix, monitor, and control small volume of fluids.
► Micro/nanofluidics has the potential to revolutionize the process and products that use fluid by high integration with a process.

4. Figure 1. Downscaling of volumes
Micro-/nanofluidics
Figure 1. Downscaling of volumes

5. Microfluidics in nature
Biomimetic surface
In vivo
Surface tension

6. Nanofluidics in nature
EDL overlap
Aquaporins
Ion channel

7. Transport at different length scale
Nanofluidic toolbox

8. Basic properties in Microfluidics
► All flow is laminar (no turbulent mixing)
► Surface tension becomes significant
► No inertia effects
► Apparent viscosity increases

9. Microfluidic channels
Variety of shapes and manufacturing techniques,
depending on application.
Typically laminar due to very small length scales
and flow rates.

10. Laminar Flow in Microfluidic Channels 

11. Multiscale microfluidic elements

12. Master fabrication

13. PDMS mold: wonder material for BioMEMS

14. PDMS mold

15. Channel Fabrication – Example

16. Advantages of Microfluidics

17. Microfluidic Systems for uTAS

18. Synthesis with Micro reactor

19. Drug Delivery Microchip
J. Santini and R. Langer, MIT

20. Drug Delivery Micro Needles

21. Scaling in Micro-/nanofluidics

22. Scaling in Micro-/nanofluidics

23. Scaling in Micro-/nanofluidics

24. Scaling in Micro-/nanofluidics

25. Scaling in Micro-/nanofluidics

26. Scaling in Micro-/nanofluidics

27. Scaling in Micro-/nanofluidics

28. Scaling in Micro-/nanofluidics

29. Scaling in Micro-/nanofluidics