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C tNHA9::cd41 3 dpf cd41 D.

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Presentation on theme: "C tNHA9::cd41 3 dpf cd41 D."— Presentation transcript:

1 C tNHA9::cd41 3 dpf cd41 D

2 Supplemental Figure S2 C A B Uninjected meis1 MO tNHA9 gata1
rNHA9

3 Supplemental Figure S3 A B C D 0.3% DMSO 10 μM Indo 10 μM NS-398 WT
gata1 tNHA9 B 0.3% DMSO 10 μM Indo 10 μM NS-398 WT runx1 & c-myb tNHA9 C D

4 Supplemental Figure S4 A WT B tNHA9 18 hpf 36 hpf dmnt1 48 hpf

5 Supplemental Figure S5 A B C D B E F
Coverage Downregulated Promoters p value lGl vs tNHA9 lGl vs tNHA9 DAC+VPA o/n lGl vs tNHA9 DAC o/n lGl vs tNHA9 DAC tNHA9 vs tNHA9 DAC tNHA9 vs tNHA9 DAC+VPA 9.49E-05 tNHA9 vs tNHA9 DAC o/n tNHA9 vs tNHA9 DAC+VPA o/n Coverage in Downregulated Promoters C lGl tNHA tNHA9-DAC tNHA9-DAC+VPA tNHA9-DAC o/n tNHA9-DAC+VPA o/n D All Down-regulated Upregulated Number of CpGs in Promoters Number of CpGs in promoters 2-sided t test Upregulated vs. Downregulated Upregulated vs. All Downregulated vs. All B E F Upregulated gene bodies p-values lGl vs tNHA9 lGl vs tNHA9 DAC+VPA o/n lGl vs tNHA9 DAC o/n lGl vs tNHA9 DAC tNHA9 vs tNHA9 DAC tNHA9 vs tNHA9 DAC+VPA 9.49E-05 tNHA9 vs tNHA9 DAC o/n tNHA9 vs tNHA9 DAC+VPA o/n Coverage in tNHA9 gene-bodies of up-regulated genes lGl tNHA tNHA9-DAC tNHA9-DAC+VPA tNHA9-DAC o/n tNHA9-DAC+VPA o/n

6 Supplemental Figure S6 A B C D E F G

7 Supplemental Figure S7 A B C D Uninjected uhrf1 MO WT lcp1 tNHA9
dnmt1 MO uhrf1 MO WT gata1 tNHA9 D

8 Supplemental Figure S8 A B C D E F 250 μM Zeb WT lcp1 tNHA9 Uninjected
250 μM DAC WT gata1 tNHA9 F

9 Supplemental Figure S9 A B C MeDIP Signal
Position Relative to TSS in all Ensembl Zv9 genes B C MeDIP Signal Position Relative to TSS in all Ensembl Zv9 genes All Promoter Profiles p-value 20-bin lGl vs tNHA9 4.52E-108 lGl vs tNHA9 DAC+VPA o/n lGl vs tNHA9 DAC o/n lGl vs tNHA9 DAC 9.21E-12 lGl vs tNHA9 DAC+VPA tNHA9 vs tNHA9 DAC 5.40E-139 tNHA9 vs tNHA9 DAC+VPA 1.68E-114 tNHA9 vs tNHA9 DAC o/n 1.34E-90 tNHA9 vs tNHA9 DAC+VPA o/n 7.92E-106

10 Supplemental Figure S10 A B C D E F 600 nM TSA 25 μM DAC + 125 nM TSA
WT lcp1 tNHA9

11 Supplemental Figure S11 A B C D 0.3% DMSO 250 μM VPA 600 nM TSA WT
gata1 tNHA9 B C 0.3% DMSO 10 μM DAC + 25 μM VPA 25 μM DAC nM TSA WT lcp1 tNHA9 D

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