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Josep M. Llovet  Clinical Gastroenterology and Hepatology 

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Presentation on theme: "Josep M. Llovet  Clinical Gastroenterology and Hepatology "— Presentation transcript:

1 Hepatocellular Carcinoma: Patients With Increasing Alpha-Fetoprotein But No Mass on Ultrasound 
Josep M. Llovet  Clinical Gastroenterology and Hepatology  Volume 4, Issue 1, Pages (January 2006) DOI: /S (05) Copyright © 2006 American Gastroenterological Association Terms and Conditions

2 Figure 1 Receiver operating characteristic curve of serum AFP level to discriminate between cirrhotic patients with and without HCC. Reprinted with permission from Trevisani et al,6 © 2001 The European Association for the Study of the Liver. Clinical Gastroenterology and Hepatology 2006 4, 29-35DOI: ( /S (05) ) Copyright © 2006 American Gastroenterological Association Terms and Conditions

3 Figure 2 Surveillance and recall strategy for HCC. Endorsed by the EASL panel of experts on HCC. *Available for curative treatments if diagnosed with HCC. **AFP levels to be defined. ***Pathologic confirmation or noninvasive criteria. Reprinted with permission from Bruix et al,2 © 2001 The European Association for the Study of the Liver. Clinical Gastroenterology and Hepatology 2006 4, 29-35DOI: ( /S (05) ) Copyright © 2006 American Gastroenterological Association Terms and Conditions

4 Figure 3 Diagnostic algorithm for patients with increased AFP levels (>400 ng/mL) and normal US. *Diagnosis obtained in most of the patients. **Almost never needed currently. Aids in diffuse HCC diagnosis. ***Anecdotic use. Aids in diffuse HCC diagnosis. mets, metastases. Clinical Gastroenterology and Hepatology 2006 4, 29-35DOI: ( /S (05) ) Copyright © 2006 American Gastroenterological Association Terms and Conditions


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