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TTBK2 Kinase: Linking Primary Cilia and Cerebellar Ataxias

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Presentation on theme: "TTBK2 Kinase: Linking Primary Cilia and Cerebellar Ataxias"— Presentation transcript:

1 TTBK2 Kinase: Linking Primary Cilia and Cerebellar Ataxias
Peter K. Jackson  Cell  Volume 151, Issue 4, Pages (November 2012) DOI: /j.cell Copyright © 2012 Elsevier Inc. Terms and Conditions

2 Figure 1 Centriole Duplication Occurs during the Mitotic Cell Cycle
Serum withdrawal induces cell-cycle exit and the recruitment of the centriole to the apical surface of cells via the distal appendage and dynein-based microtubule traffic to the subdistal appendage. The TTBK2 kinase is recruited to the centriole and transition zone near the ciliary base, and causes the loss of CP110, an inhibitor of axonemal growth, thereby licensing growth of the axoneme, assembly of the preciliary vesicle ciliary, and recruitment of intraflagellar transport proteins, including IFT-B. IFT-B plays an additional role in axonemal and ciliary membrane growth and in the maintenance of the mature cilium. Cell  , DOI: ( /j.cell ) Copyright © 2012 Elsevier Inc. Terms and Conditions

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