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An Unexpected Role for TRPV4 in Serotonin-Mediated Itch
Lindsey M. Snyder, Marissa S. Kuzirian, Sarah E. Ross Journal of Investigative Dermatology Volume 136, Issue 1, Pages 7-9 (January 2016) DOI: /j.jid Copyright © 2015 The Authors Terms and Conditions
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Figure 1 TRPV4 is a key mediator of serotonin-induced itch. Akiyama et al. (2016) provide evidence that the serotonin receptor (5-HTR, blue) couples to TRPV4 (red) to mediate the activation of primary sensory afferents, which triggers itch. Journal of Investigative Dermatology , 7-9DOI: ( /j.jid ) Copyright © 2015 The Authors Terms and Conditions
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