1. Differences in microbiome between control and BPA-exposed rabbit offspring and dams according to linear discriminant analysis effect size (LEfSe).
Differences in microbiome between control and BPA-exposed rabbit offspring and dams according to linear discriminant analysis effect size (LEfSe). Publicly available LEfSe visualization tools were used to generate these graphical outputs using BPA and control as class variables for colon, cecum, and fecal samples from offspring and fecal samples from dams separately. (A to D) Histogram of the linear discriminant analysis (LDA) scores calculated for features that were differentially abundant between BPA-treated and control rabbits. LDA scores that were elevated in control dams or offspring are shown in green, whereas LDA scores that were greater in BPA-treated dams or offspring are shown in red. Significant differences were identified by the use of the LEfSe algorithm with P < 0.05 for both the Kruskal-Wallis test and Wilcoxon test. (E to H) Relative abundances (%) of taxa that were significantly different between control and BPA treatments using the LEfSe algorithm. *, significance of results of comparisons between treatments at P ≤ 0.05 using the Wilcoxon rank sum test. **, significance at P ≤ 0.05 using Bonferroni correction. $, significance at P ≤ 0.1 using Bonferroni correction.
Lavanya Reddivari et al. mSystems 2017; doi: /mSystems