1. Volume 149, Issue 2, Pages 367-378.e5 (August 2015)
Weight Loss Through Lifestyle Modification Significantly Reduces Features of Nonalcoholic Steatohepatitis 
Eduardo Vilar-Gomez, Yadina Martinez-Perez, Luis Calzadilla-Bertot, Ana Torres-Gonzalez, Bienvenido Gra-Oramas, Licet Gonzalez- Fabian, Scott L. Friedman, Moises Diago, Manuel Romero-Gomez 
Gastroenterology 
Volume 149, Issue 2, Pages e5 (August 2015)
DOI: /j.gastro
Copyright © 2015 AGA Institute Terms and Conditions

2. Figure 1
Flow of participants through the study. ∗Overall outcomes were imputed using a model of multiple imputations.
Gastroenterology  , e5DOI: ( /j.gastro )
Copyright © 2015 AGA Institute Terms and Conditions

3. Figure 2
Correlation between weight-loss percentage and improvement of different histologic parameters related to NASH. (A) Resolution of steatohepatitis, (B) NAS improvement, (C) steatosis improvement, (D) lobular inflammation improvement, (E) ballooning improvement, (F) Fibrosis status. Spearman's correlation (ρ) coefficients were computed to determine correlation between weight losses (%) and histologic features improvements. Dashed lines represent mean weight loss (%) values. Patients with small difference in the amounts of weight loss (eg, 3.2, 3.4, and 3.6) can be included in the same circle. Mean weight loss for histologic outcomes: Resolution of steatohepatitis (yes, 8.34; 95% confidence interval [CI]: 7.34−9.33]; no, 2.48; 95% CI: 2.08−2.88), NAS improvement (yes, 6.17; 95% CI: 5.41−6.93; no, 1.91; 95% CI: 1.50−2.32), steatosis improvement (yes, 6.16; 95% CI: 5.43−6.88; no, 1.81; 95% CI: 1.39−2.24), lobular inflammation improvement (yes, 5.89; 95% CI: 5.14−6.64; no, 1.94; 95% CI: 1.53−2.34), ballooning improvement (yes, 6.10; 95% CI: 5.24−6.95; no, 2.51; 95% CI: 2.05−2.98), fibrosis status (regressed, 5.39; 95% CI: 4.01−6.76; stabilized, 3.91; 95% CI: 3.34−4.49; worsened, 2.38; 95% CI: 1.48−3.27).
Gastroenterology  , e5DOI: ( /j.gastro )
Copyright © 2015 AGA Institute Terms and Conditions

4. Figure 3
Weight-loss categories and changes in the fibrosis status at the end of intervention. Analysis stratifying by presence of baseline fibrosis. (A) Presence of baseline fibrosis, (B) absence of baseline fibrosis. ∗P values for the Mantel-Haenszel χ2 test for trend stratified by age older than 55 years, sex, BMI ≥35, type 2 diabetes, medication of diabetes/hyperlipidemia, and baseline fibrosis score.
Gastroenterology  , e5DOI: ( /j.gastro )
Copyright © 2015 AGA Institute Terms and Conditions