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Expression of Nuclear Factor-κB and Its Clinical Significance in Nonsmall-Cell Lung Cancer  Zhenfa Zhang, MD, Jianqun Ma, MD, Ni Li, PhD, Nan Sun, MD,

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Presentation on theme: "Expression of Nuclear Factor-κB and Its Clinical Significance in Nonsmall-Cell Lung Cancer  Zhenfa Zhang, MD, Jianqun Ma, MD, Ni Li, PhD, Nan Sun, MD,"— Presentation transcript:

1 Expression of Nuclear Factor-κB and Its Clinical Significance in Nonsmall-Cell Lung Cancer 
Zhenfa Zhang, MD, Jianqun Ma, MD, Ni Li, PhD, Nan Sun, MD, Changli Wang, BM  The Annals of Thoracic Surgery  Volume 82, Issue 1, Pages (July 2006) DOI: /j.athoracsur Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions

2 Fig 1 Expression of nuclear factor (NF)-κB in nonsmall-cell lung cancer by Western blotting. Lung cancer tissue samples were analyzed by probing with an anti–NF-κB polyclonal antibody. The blots were subsequently probed with anti-actin antibody as a loading control. The expression level of NF-κB in each band was semiquantified by calculating the ratio of NF-κB to β-actin. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions

3 Fig 2 Scatter graph for correlation between nuclear factor (NF)-κB and caspase-3, p53, and COX-2. (A) Expression of NF-κB and caspase-3. The linear regression equation was y = x (p = 0.000), and the correlation coefficient was (p = 0.000). (B) Expression of NF-κB and p53. The linear regression equation was y = x (p = 0.000), and the correlation coefficient was (p = 0.000). (C) Expression of NF-κB and COX-2. The linear regression equation was y = x (p = 0.000), and the correlation coefficient was (p = 0.000). The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions

4 Fig 3 This chart illustrates the correlation between expression of nuclear factor (NF)-κB and overall survival among patients with nonsmall-cell lung cancer. Survival distributions were calculated with the Kaplan-Meier method and were compared in a log-rank analysis (+: censored; p = ). Nuclear factor-κB is expressed as ratio to actin expression. Nuclear factor-κB(-): median survival time, 52 months; 95% confidence interval: 48 to 55. Nuclear factor-κB(+): median survival time, 20 months; 95% confidence interval: 17 to 23. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions

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