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Operability assessment in CTEPH: Lessons from the CHEST-1 study

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Presentation on theme: "Operability assessment in CTEPH: Lessons from the CHEST-1 study"— Presentation transcript:

1 Operability assessment in CTEPH: Lessons from the CHEST-1 study
David P. Jenkins, BSc, MBBS, FRCS (CTh), MS, Andrzej Biederman, MD, Andrea M. D'Armini, MD, Philippe G. Dartevelle, MD, Hui-Li Gan, MD, Walter Klepetko, MD, Jaroslav Lindner, MD, Eckhard Mayer, MD, Michael M. Madani, MD  The Journal of Thoracic and Cardiovascular Surgery  Volume 152, Issue 3, Pages e3 (September 2016) DOI: /j.jtcvs Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions

2 Figure 1 Images and examinations used by the investigators to diagnose patients as “inoperable” prior to referral for central or local adjudication. CT, Computed tomography; VQ, ventilation/perfusion. The Journal of Thoracic and Cardiovascular Surgery  , e3DOI: ( /j.jtcvs ) Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions

3 Figure 2 Patient disposition: patients considered inoperable, operable, or in whom operability assessment was not possible; and randomized and treated patients in the CHEST-1 study. PH, Pulmonary hypertension; PEA, pulmonary endarterectomy. The Journal of Thoracic and Cardiovascular Surgery  , e3DOI: ( /j.jtcvs ) Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions

4 Figure E1 Current recommendation for diagnosis and operability assessment in CTEPH. Figure based on Jenkins and colleagues.6 CTEPH, Chronic thromboembolic pulmonary hypertension; VQ, ventilation/perfusion; CT, computed tomography; MR, magnetic resonance. The Journal of Thoracic and Cardiovascular Surgery  , e3DOI: ( /j.jtcvs ) Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions

5 Figure E2 Template forms completed by adjudicators for (A) operability assessment information and (B) operability assessment report. CTEPH, Chronic thromboembolic pulmonary hypertension; WHO, World Health Organization; CHEST-1, Chronic Thromboembolic Pulmonary Hypertension Soluble Guanylate Cyclase-Stimulator Trial-1; MRI, magnetic resonance imaging; CT, computed tomography; VQ, ventilation/perfusion. The Journal of Thoracic and Cardiovascular Surgery  , e3DOI: ( /j.jtcvs ) Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions

6 Figure E2 Template forms completed by adjudicators for (A) operability assessment information and (B) operability assessment report. CTEPH, Chronic thromboembolic pulmonary hypertension; WHO, World Health Organization; CHEST-1, Chronic Thromboembolic Pulmonary Hypertension Soluble Guanylate Cyclase-Stimulator Trial-1; MRI, magnetic resonance imaging; CT, computed tomography; VQ, ventilation/perfusion. The Journal of Thoracic and Cardiovascular Surgery  , e3DOI: ( /j.jtcvs ) Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions

7 Classification of surgical eligibility after operability assessment in the CHEST-1 study.
The Journal of Thoracic and Cardiovascular Surgery  , e3DOI: ( /j.jtcvs ) Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions


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