1. Poly-l-Arginine Topical Lotion Tested in a Mouse Model for Frostbite Injury 
Lauren J. Auerbach, BS, Brittney K. DeClerk, MD, C. Garrison Fathman, MD, Geoffrey C. Gurtner, MD, Paul S. Auerbach, MD, MS 
Wilderness & Environmental Medicine 
Volume 25, Issue 2, Pages (June 2014)
DOI: /j.wem
Copyright © 2014 Wilderness Medical Society Terms and Conditions

2. Figure 1
Gross appearance of wound progression at various times after induced frostbite injury under different treatment conditions. Variations among treatments can be seen at intermediate times, although all wounds were completely healed by day 27.
Wilderness & Environmental Medicine  , DOI: ( /j.wem )
Copyright © 2014 Wilderness Medical Society Terms and Conditions

3. Figure 2
Wound healing showing the percentage of original wound area healed by day. Each data point used to create a curve is the mean healed percentage (confidence interval = 97%) of the original wound area for all mice treated for that condition.
Wilderness & Environmental Medicine  , DOI: ( /j.wem )
Copyright © 2014 Wilderness Medical Society Terms and Conditions

4. Figure 3
Percentage surface area of tissue lost within the tattooed boundary compared with the original surface area within the boundary. Mice pretreated with poly-l-arginine before the frostbite injury lost less tissue than did mice under any other treatment condition. Each data point used to create a curve is the mean percentage (confidence interval = 95%) loss of the original tattooed area for all mice treated for that condition.
Wilderness & Environmental Medicine  , DOI: ( /j.wem )
Copyright © 2014 Wilderness Medical Society Terms and Conditions