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A rapid chemokine response of macrophage inflammatory protein (MIP)-1α, MIP-1β and the regulated on activation, normal T expressed and secreted chemokine.

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Presentation on theme: "A rapid chemokine response of macrophage inflammatory protein (MIP)-1α, MIP-1β and the regulated on activation, normal T expressed and secreted chemokine."— Presentation transcript:

1 A rapid chemokine response of macrophage inflammatory protein (MIP)-1α, MIP-1β and the regulated on activation, normal T expressed and secreted chemokine is associated with a sustained virological response in the treatment of chronic hepatitis C  J. Florholmen, M.G. Kristiansen, S.E. Steigen, S.W. Sørbye, E.J. Paulssen, J.M. Kvamme, Z. Konopski, T. Gutteberg, R. Goll  Clinical Microbiology and Infection  Volume 17, Issue 2, Pages (February 2011) DOI: /j x Copyright © 2011 European Society of Clinical Infectious Diseases Terms and Conditions

2 FIG. 1 Early serum chemokine responses to the treatment of chronic hepatitis C virus infection. Values are geometric means (95% CI for geometric mean); p values are generated by a t-test of 0–24 h within group (long underline) and between group (short underline) differences. Clinical Microbiology and Infection  , DOI: ( /j x) Copyright © 2011 European Society of Clinical Infectious Diseases Terms and Conditions

3 FIG. 2 Receiver-operator characteristics for the macrophage inflammatory protein (MIP)-1α and MIP-1β increase at 24 h after the initiation of interferon-α therapy. The basis of this analysis is a continuous variable (chemokine value) and an actual state variable [sustained virological response (SVR)/no SVR]. A choice of cut-off will define values as being positive or negative, and a comparison of this value with the actual state gives the estimate of sensitivity and specificity. Different cut-off values then define the blue curve in the plot. Both observed areas are significant and cut-off values can be deduced by inspecting the plot coordinates and their corresponding chemokine values (not shown). Clinical Microbiology and Infection  , DOI: ( /j x) Copyright © 2011 European Society of Clinical Infectious Diseases Terms and Conditions


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