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Potential mechanisms whereby statins may reduce the risk of stroke

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Presentation on theme: "Potential mechanisms whereby statins may reduce the risk of stroke"— Presentation transcript:

1 Potential mechanisms whereby statins may reduce the risk of stroke
P. Amarenco, et al. Arch Med Sci 2007;3:S109-S114

2 Stroke risk reduction according to
LDL-cholesterol reduction (%) in statin trials P. Amarenco, et al. Arch Med Sci 2007;3:S109-S114

3 Net benefit of treatment with atorvastatin 80 mg/day in patients with recent stroke or transient ischemic attack (analysis of incidence of hemorrhagic stroke was post hoc) in the SPARCL trial Left panel: primary endpoint stroke fatal or non. Right panel: secondary endpoint major cardiovascular events (stroke fatal or non and major coronary events) P. Amarenco, et al. Arch Med Sci 2007;3:S109-S114

4 Meta-analysis of four statin trials that evaluated the effect of intensive lipid-lowering therapy versus standard statin therapy: fatal and nonfatal stroke incidence P. Amarenco, et al. Arch Med Sci 2007;3:S109-S114

5 Meta-analysis of four statin trial that evaluated the effect of intensive lipid-lowering therapy versus standard statin therapy: major cardiovascular events (including stroke, myocardial infarction and vascular death) P. Amarenco, et al. Arch Med Sci 2007;3:S109-S114


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