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International Journal of Cardiology

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1 International Journal of Cardiology
Positron emission tomography/computed tomography detection of increased 18F- fluorodeoxyglucose uptake in the cardiac atria of patients with atrial fibrillation  Emiri Watanabe, Masao Miyagawa, Teruyoshi Uetani, Masaki Kinoshita, Riko Kitazawa, Mie Kurata, Hayato Ishimura, Takuya Matsuda, Yuki Tanabe, Tomoyuki Kido, Teruhito Kido, Akira Kurata, Teruhito Mochizuki  International Journal of Cardiology  Volume 283, Pages (May 2019) DOI: /j.ijcard Copyright © 2018 The Authors Terms and Conditions

2 Fig. 1 A male patient in his 50s had undergone a lung cancer surgery 14 years previously, and was followed up by several PET/CT examinations. He had severe atrial tachyarrhythmia when PET/CT imaging was performed, prior to ablation therapy. (A) Avid accumulation of FDG was found in the right atrium (RA) appendage and free wall, atrial septum, left atrium (LA) appendage, and LA anterior and posterior walls (RA target-to-background ratio [TBR]: 5.00; LA TBR: 5.85). (B) Ten months later, he received additional treatment with cardioversion for relapsed atrial fibrillation, which was effective. Normal sinus rhythm was restored. At the 1-year PET/CT follow-up study, no FDG uptake was observed in either atrium (RA TBR: 1.29; LA TBR: 1.71). MIP indicates maximum intensity projection. International Journal of Cardiology  , DOI: ( /j.ijcard ) Copyright © 2018 The Authors Terms and Conditions

3 Fig. 2 A male patient in his 80s who had experienced persistent lone atrial fibrillation (AF) for >7 years underwent PET/CT imaging as a pretreatment examination for duodenal cancer. (A) He had grade 2 FDG accumulation in the right atrium (RA) (arrow). Pathological investigation of the heart was conducted at his autopsy performed 3 months after the PET/CT. (B) Histopathology of the pericardium of the RA appendage. Hematoxylin–eosin (H&E) staining shows lymphocyte infiltration around blood vessels in adipose tissue (×200). Numerous CD68-positive macrophages had infiltrated the whole pericardial tissue. Lymphocytes are partly positive for CD3 and CD20 (×200). MIP indicates maximum intensity projection. International Journal of Cardiology  , DOI: ( /j.ijcard ) Copyright © 2018 The Authors Terms and Conditions

4 Supplemental Fig. 1 A female patient in her 60s with paroxysmal atrial fibrillation underwent 18F-fluorodeoxyglucose positron-emission tomography/computed tomography (FDG-PET/CT). (A) MIP indicates maximum intensity projection. (B) Regions of interest encompassing the cardiac atria were manually drawn on the transaxial and coronal fusion images. International Journal of Cardiology  , DOI: ( /j.ijcard ) Copyright © 2018 The Authors Terms and Conditions

5 Supplemental Fig. 2 Relationship between the visual grading and the right atrial (RA) target-to-background ratio (TBR) (left) and the left atrial (LA) TBR (right). In both atria, there were significant differences between grades 1 and 2, and between grades 2 and 3, but not between grades 0 and 1. N.S. indicates not significant. International Journal of Cardiology  , DOI: ( /j.ijcard ) Copyright © 2018 The Authors Terms and Conditions


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