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Mona Malz, Federico Pinna, Peter Schirmacher, Kai Breuhahn 

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Presentation on theme: "Mona Malz, Federico Pinna, Peter Schirmacher, Kai Breuhahn "— Presentation transcript:

1 Transcriptional regulators in hepatocarcinogenesis – Key integrators of malignant transformation 
Mona Malz, Federico Pinna, Peter Schirmacher, Kai Breuhahn  Journal of Hepatology  Volume 57, Issue 1, Pages (July 2012) DOI: /j.jhep Copyright © 2012 European Association for the Study of the Liver Terms and Conditions

2 Fig. 1 Modes of dysregulation of transcriptional regulators (TR) in human HCC cells (red) including mutations of upstream signalling pathway components (e.g., receptors and pathway constituents), mutations, and genomic alterations. Possibilities of pathway interference (blue) include the inhibition of receptor tyrosine kinase (RTK) inhibitors, expression of pathway antagonists, and inhibitors of TR-dimerization and TR/DNA interaction. Virotherapy links TRs activity with viral replication and oncolysis. Journal of Hepatology  , DOI: ( /j.jhep ) Copyright © 2012 European Association for the Study of the Liver Terms and Conditions

3 Journal of Hepatology 2012 57, 186-195DOI: (10. 1016/j. jhep. 2011. 11
Copyright © 2012 European Association for the Study of the Liver Terms and Conditions


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